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| | ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE Basic information |
| Product Name: | ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE | | Synonyms: | TIMTEC-BB SBB003473;3-CARBETHOXY-4-PIPERIDONE HCL;3-CARBETHOXY-4-PIPERIDONE HYDROCHLORIDE;LABOTEST-BB LT00455216;ETHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE;ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE;3-Carboethoxy-4-piperidone hydrochloride~Ethyl 4-oxo-piperidine-3-carboxylate hydrochloride;ethyl 4-oxopiperidine-3-carboxylate | | CAS: | 4644-61-5 | | MF: | C8H14ClNO3 | | MW: | 207.65 | | EINECS: | 225-073-8 | | Product Categories: | | | Mol File: | 4644-61-5.mol |  |
| | ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE Chemical Properties |
| Melting point | 169-175 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Water Solubility | Soluble in water | | form | powder to crystal | | color | White to Brown | | BRN | 3711279 | | InChI | InChI=1S/C8H13NO3.ClH/c1-2-12-8(11)6-5-9-4-3-7(6)10;/h6,9H,2-5H2,1H3;1H | | InChIKey | RTYXWLMQWSFXNI-UHFFFAOYSA-N | | SMILES | C1(CNCCC1=O)C(=O)OCC.Cl | | CAS DataBase Reference | 4644-61-5(CAS DataBase Reference) |
| | ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | white to yellow crystalline powder | | Uses | Ethyl 4-piperidone-3-carboxylate, HCl | | Synthesis | General procedure for the synthesis of ethyl piperidin-4-one-3-carboxylate hydrochloride from ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride: in a 50 mL reactor, ethyl N-benzyl-4-oxo-piperidine-3-carboxylate hydrochloride (12 g, 40.29 mmol) and Pd(OH)2/C catalyst (120 mg, 1 wt%) were added. The reaction was stirred for 48 h under 5 bar hydrogen pressure using a dry solvent mixture of dichloromethane and methanol (4:1, v/v) as the reaction medium. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad followed by evaporation of the solvent under reduced pressure to afford 8.3 g of the target product, ethyl piperidin-4-one-3-carboxylate hydrochloride, as a light brown solid in 99% yield. | | References | [1] Tetrahedron, 1991, vol. 50, # 2, p. 515 - 528
[2] Tetrahedron Letters, 2012, vol. 53, # 26, p. 3296 - 3300
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1784 - 1796
[4] Archiv der Pharmazie, 2018, vol. 351, # 9,
[5] Patent: CN108586454, 2018, A. Location in patent: Paragraph 0134; 0136; 0137 |
| | ETHYL 4-PIPERIDONE-3-CARBOXYLATE HYDROCHLORIDE Preparation Products And Raw materials |
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