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| | Hydroxy-Amino-(PEG2-t-butyl ester)2 Basic information |
| Product Name: | Hydroxy-Amino-(PEG2-t-butyl ester)2 | | Synonyms: | Hydroxy-Amino-(PEG2-t-butyl ester)2;Hydroxy-Amino-bis(PEG1-t-butyl ester);Hydroxy-Amino-bis(PEG1-C2-Boc);4,10,14-Trioxa-7-azahexadecanoic acid, 7-(2-hydroxyethyl)-15,15-dimethyl-13-oxo-, 1,1-dimethylethyl ester;Hydroxy-amino-(peg1-t-butyl ester)2 | | CAS: | 1415800-34-8 | | MF: | C20H39NO7 | | MW: | 405.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1415800-34-8.mol |  |
| | Hydroxy-Amino-(PEG2-t-butyl ester)2 Chemical Properties |
| Boiling point | 478.7±35.0 °C(Predicted) | | density | 1.058±0.06 g/cm3(Predicted) | | pka | 14.68±0.10(Predicted) |
| | Hydroxy-Amino-(PEG2-t-butyl ester)2 Usage And Synthesis |
| Description | Hydroxy-Amino-bis(PEG1-t-butyl ester) is a branched PEG linker with a terminal hydroxy group and two t-butyl esters. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions. | | Uses | Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Hydroxy-Amino-(PEG2-t-butyl ester)2 Preparation Products And Raw materials |
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