- Boc-Sar-OL
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2026-09-15
- CAS:57561-39-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | (2-Hydroxyethyl)methylcarbamic acid 1,1-dimethylethyl ester Basic information |
| | (2-Hydroxyethyl)methylcarbamic acid 1,1-dimethylethyl ester Chemical Properties |
| Boiling point | 120-126°C 4mm | | density | 1.037±0.06 g/cm3(Predicted) | | refractive index | 1.4410 to 1.4460 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 14.67±0.10(Predicted) | | form | Liquid | | color | Colorless to pale yellow | | Water Solubility | Soluble in diochloromethane. Slightly soluble in water. | | InChI | InChI=1S/C8H17NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h10H,5-6H2,1-4H3 | | InChIKey | RFDSJHHLGFFVHD-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)N(CCO)C |
| Safety Statements | 24/25 | | HS Code | 2924297099 |
| | (2-Hydroxyethyl)methylcarbamic acid 1,1-dimethylethyl ester Usage And Synthesis |
| Uses | N-Boc-N-methylethanolamine is an substituent in the synthesis of anticancer agent, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription. | | Synthesis | General procedure: To a solution of 2-(methylamino)ethanol (500 mg, 0.53 mL, 6.66 mmol) in dichloromethane (20 mL) was added di-tert-butyl dicarbonate (1.48 g, 6.79 mmol), and the reaction was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was extracted with saturated aqueous sodium chloride solution and dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give N-BOC-N-methylaminoethanol (colorless oil, quantitative yield). The product was characterized as follows: 1H NMR (200 MHz, CDCl3) δ 3.74 (q, J = 10.5, 5.2 Hz, 2H), 3.25 (t, J = 5.2 Hz, 2H), 2.91 (s, 3H), 1.45 (s, 9H); mass spectra m/z (relative intensities) 144 (20), 102 (24), 57 (70), 44 (100). | | References | [1] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6368 - 6380
[2] Patent: US2009/42872, 2009, A1. Location in patent: Page/Page column 19
[3] Patent: US2007/4675, 2007, A1. Location in patent: Page/Page column 92-93
[4] Patent: WO2007/81091, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2011/5028, 2011, A2. Location in patent: Page/Page column 11 |
| | (2-Hydroxyethyl)methylcarbamic acid 1,1-dimethylethyl ester Preparation Products And Raw materials |
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