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| | 2-Bromo-5-fluorobenzyl alcohol Basic information |
| | 2-Bromo-5-fluorobenzyl alcohol Chemical Properties |
| Melting point | 91-94 °C | | Boiling point | 252.5±25.0 °C(Predicted) | | density | 1.658±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.67±0.10(Predicted) | | form | Solid | | color | Yellow | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C7H6BrFO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4H2 | | InChIKey | HXGZPMHPSBJMKB-UHFFFAOYSA-N | | SMILES | C1(CO)=CC(F)=CC=C1Br | | CAS DataBase Reference | 202865-66-5(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-36-22 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2906290090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 2-Bromo-5-fluorobenzyl alcohol Usage And Synthesis |
| Chemical Properties | Colorless liquid | | Uses | 2-Bromo-5-fluorobenzyl alcohol is used as intermediates in pharmaceutical and organic synthesis. | | Synthesis | General procedure for the synthesis of 2-bromo-5-fluorobenzyl alcohol from 2-bromo-5-fluorobenzaldehyde: To a solution of 2-bromo-5-fluorobenzaldehyde (75.0 g, 369 mmol) in ethanol (375 mL) was slowly added a solution of sodium borohydride (4.47 g, 118 mmol) in water (9 mL) at 0 °C. The reaction mixture was kept stirred at 0°C for 1 hour. Upon completion of the reaction, the mixture was treated with water and ethyl acetate and extracted with ethyl acetate. The combined organic extracts were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 75.6 g of 2-bromo-5-fluorobenzyl alcohol (yield = 99.8%) as a colorless solid.1H NMR (CDCl3) δ 7.50-7.46 (1H, m), 7.29-7.25 (1H, m), 6.92-6.85 (1H, m), 4.72 (2H, s). | | References | [1] Journal of Organic Chemistry, 2005, vol. 70, # 2, p. 756 - 759
[2] Patent: WO2007/19098, 2007, A2. Location in patent: Page/Page column 44
[3] Tetrahedron, 2007, vol. 63, # 38, p. 9401 - 9405
[4] Patent: CN108358961, 2018, A. Location in patent: Paragraph 0016; 0057; 0058-0060; 0062; 0069; 0071; 0078
[5] CrystEngComm, 2014, vol. 16, # 23, p. 4999 - 5011 |
| | 2-Bromo-5-fluorobenzyl alcohol Preparation Products And Raw materials |
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