| Identification | Back Directory | [Name]
Aminooxy-PEG4-alcohol | [CAS]
106492-60-8 | [Synonyms]
Aminooxy-PEG4-alcohol
2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethanol
Ethanol, 2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C8H19NO5 | [MDL Number]
MFCD30828691 | [MOL File]
106492-60-8.mol | [Molecular Weight]
209.24 |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG4-alcohol is an aqueous soluble PEG reagent. The aminooxy group can react with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. | [IC 50]
PEGs; Non-cleavable Linker | [References]
[1] Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c |
|
|