| Identification | Back Directory | [Name]
Aminoxy-PEG4-acid | [CAS]
1807537-38-7 | [Synonyms]
Aminoxy-PEG4-acid
Aminoxy-PEG4-COOH
Aminooxy-PEG4-acid
Aminooxy-PEG4-COOH
Aminooxy-PEG4-acid HCl salt | [Molecular Formula]
C11H23NO7 | [MDL Number]
MFCD28015778 | [MOL File]
1807537-38-7.mol | [Molecular Weight]
281.3 |
| Chemical Properties | Back Directory | [Boiling point ]
448.6±45.0 °C(Predicted) | [density ]
1.170±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG4-acid is a PEG linker containing an aminooxy group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. Aminooxy-PEG4-acid is not stable as a neat compound; it is sold as 1.0M aqueous solution. | [Uses]
Aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
| Company Name: |
Henan Alfachem Co.,Ltd.
|
| Tel: |
0371-55051623 18137891487 |
| Website: |
www.chemicalbook.com/supplier/14555231/ |
|