| Identification | Back Directory | [Name]
Aminooxy-PEG4-t-butyl ester | [CAS]
2100306-82-7 | [Synonyms]
Aminooxy-PEG4-C2-Boc
Aminooxy-PEG4-t-butyl ester
4,7,10,13-Tetraoxapentadecanoic acid, 15-(aminooxy)-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H31NO7 | [MDL Number]
MFCD30730368 | [MOL File]
2100306-82-7.mol | [Molecular Weight]
337.41 |
| Chemical Properties | Back Directory | [Boiling point ]
431.5±40.0 °C(Predicted) | [density ]
1.070±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.21±0.70(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG3-t-butyl ester is an aminooxy-containing PEG compound. The aminooxy group is reactive with an aldehyde to form an oxime bond, if a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester can be converted tofree acid under acidic condition. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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