| Identification | Back Directory | [Name]
Aminooxy-PEG3-NH-Boc | [CAS]
2062663-65-2 | [Synonyms]
Aminooxy-PEG3-NH-Boc
Aminooxy-PEG3-C2-NH-Boc
tert-Butyl (2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate
5,8,11-Trioxa-2-azatridecanoic acid, 13-(aminooxy)-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H28N2O6 | [MDL Number]
MFCD30536148 | [MOL File]
2062663-65-2.mol | [Molecular Weight]
308.37 |
| Chemical Properties | Back Directory | [Boiling point ]
440.0±40.0 °C(Predicted) | [density ]
1.083±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, sealed storage, away from moisture and light | [solubility ]
Soluble in DMSO, DMF, Methanol | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG3-NH-Boc is a PEG linker containing an aminooxy group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The protected amine can be deprotected under acidic conditions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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