Adamantanamine Hydrochloride
- CAS No.
- 665-66-7
- Chemical Name:
- Adamantanamine Hydrochloride
- Synonyms
- AMANTADINE HCL;AMANTADINE HYDROCHLORIDE;1-AMINOADAMANTANE HYDROCHLORIDE;ADAMANTANAMINE HYDROCHLORIDE;symmetrel;1-ADAMANTANAMINE HCL;ADAMANTAN-1-AMINE HYDROCHLORIDE;Mantadan;Amantadine hydrochlorid;(3s,5s,7s)-adamantan-1-amine hydrochloride
- CBNumber:
- CB00124262
- Molecular Formula:
- C10H18ClN
- Molecular Weight:
- 187.71
- MDL Number:
- MFCD00074723
- MOL File:
- 665-66-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C(lit.) |
|---|---|
| Boiling point | 308.63°C (rough estimate) |
| Density | 1.0276 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | H2O: 50 mg/mL |
| form | Fine Crystalline Powder |
| pka | 10.71 |
| color | White |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,374 |
| BRN | 4198854 |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-; |
| InChIKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
| SMILES | Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3 |
| LogP | -1.64 at 23℃ and pH6.3 |
| CAS DataBase Reference | 665-66-7(CAS DataBase Reference) |
| FDA UNII | M6Q1EO9TD0 |
| NCI Dictionary of Cancer Terms | amantadine hydrochloride |
| NCI Drug Dictionary | amantadine hydrochloride |
| Proposition 65 List | Amantadine Hydrochloride |
| EPA Substance Registry System | Amantadine hydrochloride (665-66-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-40-20/21/22 | |||||||||
| Safety Statements | 22-36/37-36-35-20/21 | |||||||||
| RIDADR | UN 1759 8 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU4375000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29213000 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Adamantanamine Hydrochloride price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1260 | Amantadine hydrochloride | 665-66-7 | 5g | $72.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP530 | Amantadine hydrochloride British Pharmacopoeia (BP) Reference Standard | 665-66-7 | 200MG | $282 | 2026-04-30 | Buy |
| Sigma-Aldrich | A0363000 | Amantadine hydrochloride European Pharmacopoeia (EP) Reference Standard | 665-66-7 | 100 mg | $175 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.20015 | 1-Adamantaneammonium chloride for synthesis | 665-66-7 | 10g | $72.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1018505 | Amantadine hydrochloride United States Pharmacopeia (USP) Reference Standard | 665-66-7 | 200mg | $435 | 2026-04-30 | Buy |
Adamantanamine Hydrochloride Chemical Properties, Uses, Production
Uses
Adamantanamine Hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. It is also used an NMDA-receptor antagoinst.
Synthesis
a kind of synthetic method of adamantanamine hydrochloride, comprises the steps:
1. react: 5 parts of (massfraction) sulfuric acid are joined in reaction vessel, with cold salt bath control temperature to-7 DEG C, drip 0.5 part of acetonitrile, again temperature is controlled at-3 DEG C, add 0.01 part of nickel catalyzator, then 1 part of amantadine is divided into two batches joins in above-mentioned mixed solution, after amantadine has added, be warming up to 18 DEG C, be incubated 6.5 hours;
2. be hydrolyzed: separately get a reaction vessel, add 28 parts of water, make its temperature be no more than 0 DEG C with ice bath, drip the liquid of step 1. after insulation, then add 13 parts of methylene dichloride wherein, stir 25 minutes;
3. extract: stopping is stirred and after stratification, the aqueous phase got wherein extracts with 6 parts of methylene dichloride;
4. dissolve: by the methylene dichloride evaporate to dryness after extraction, 7.5 parts of propyl carbinols are added in residue, 1 part of sodium hydroxide is added after stirring and dissolving, be heated to can carry out back flow reaction and react 7.5 hours, add 9.5 parts of water after cooling and stir 25 minutes, stop stirring treating its layering, get organic phase 4.5 parts of water washings once;
5. crystallization: stir above-mentioned organic phase, drips the hydrochloric acid 1.2 parts of 36%, and after crystallization, centrifuging obtains once thick product, once adds 10 parts of methylcarbonates again in thick product and carries out recrystallization, then after centrifugal, obtain the thick product of secondary;
6. wash drying: washed through methylcarbonate by thick for secondary product, after dry at 55 DEG C in vacuum drying oven, after drying finished product Adamantanamine Hydrochloride.
Adamantanamine Hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Shengbang Biotechnology Co., Ltd. | 13685312009 | 418162321@qq.com | China | 60 | 58 |
| Sichuan Zhongbang Pharma CO.，LTD | 0830-0830-2585019 13679670161 | sales2@zhongbangst.com | China | 105 | 69 |
| TIANJIN MINXIANG BIOMEDICAL INC. | 13313219033 | tjmx@mxpharm.com | China | 39 | 58 |
| Huzhou Chenxi Environmental Protection Technology Co., Ltd. | 16762203950 16762203950 | 3775386035@qq.com | China | 102 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
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- Nov 16,2023
View Latest Price from Adamantanamine Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-01 | Adamantanamine hydrochloride
665-66-7
|
$100.00 | 1kg | 99% | 1t | Zibo Wei Bin Import & Export Trade Co. Ltd. | |
 |
2021-07-13 | 1-Adamantanamine hydrochloride
665-66-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 1-Adamantanamine hydrochloride
665-66-7
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Adamantanamine hydrochloride
665-66-7
- $100.00
- 99%
- Zibo Wei Bin Import & Export Trade Co. Ltd.
-
- 1-Adamantanamine hydrochloride
665-66-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Adamantanamine hydrochloride
665-66-7
- $1.00
- 98%
- Career Henan Chemical Co
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