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Amantadine Hcl

Amantadine Hcl structure

CAS No.: 665-66-7

Chemical Name:: Amantadine Hcl

Synonyms: AMANTADINE HCL;AMANTADINE HYDROCHLORIDE;1-AMINOADAMANTANE HYDROCHLORIDE;ADAMANTANAMINE HYDROCHLORIDE;symmetrel;1-ADAMANTANAMINE HCL;ADAMANTAN-1-AMINE HYDROCHLORIDE;Mantadan;Amantadine hydrochlorid;(3s,5s,7s)-adamantan-1-amine hydrochloride

CBNumber:: CB00128587

Molecular Formula:: C10H18ClN

Molecular Weight:: 187.71

MDL Number:: MFCD00074723

MOL File:: 665-66-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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Amantadine Hcl Properties

Melting point	>300 °C(lit.)
Boiling point	308.63°C (rough estimate)
Density	1.0276 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Store below +30°C.
solubility	H₂O: 50 mg/mL
form	Fine Crystalline Powder
pka	10.71
color	White
Water Solubility	soluble
Sensitive	Hygroscopic
Merck	14,374
BRN	4198854
Major Application	pharmaceutical (small molecule)
InChI	1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChIKey	WOLHOYHSEKDWQH-UHFFFAOYSA-N
SMILES	Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
LogP	-1.64 at 23℃ and pH6.3
CAS DataBase Reference	665-66-7(CAS DataBase Reference)
FDA UNII	M6Q1EO9TD0
NCI Dictionary of Cancer Terms	amantadine hydrochloride
NCI Drug Dictionary	amantadine hydrochloride
Proposition 65 List	Amantadine Hydrochloride
EPA Substance Registry System	Amantadine hydrochloride (665-66-7)
UNSPSC Code	41116107
NACRES	NA.77

Pharmacokinetic data

Protein binding	67%
Excreted unchanged in urine	90%
Volume of distribution	5-10(L/kg)
Biological half-life	15 / 500

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P301+P312+P330

Hazard Codes

Risk Statements

22-40-20/21/22

Safety Statements

22-36/37-36-35-20/21

RIDADR

UN 1759 8 / PGII

WGK Germany

RTECS

AU4375000

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29213000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier)

REACH Registrations

Active

NFPA 704

	1
3		0

Amantadine Hcl price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A1260	Amantadine hydrochloride	665-66-7	5g	$72.7	2026-04-30	Buy
Sigma-Aldrich	BP530	Amantadine hydrochloride British Pharmacopoeia (BP) Reference Standard	665-66-7	200MG	$282	2026-04-30	Buy
Sigma-Aldrich	A0363000	Amantadine hydrochloride European Pharmacopoeia (EP) Reference Standard	665-66-7	100 mg	$175	2026-04-30	Buy
Sigma-Aldrich	8.20015	1-Adamantaneammonium chloride for synthesis	665-66-7	10g	$72.3	2026-04-30	Buy
Sigma-Aldrich	1018505	Amantadine hydrochloride United States Pharmacopeia (USP) Reference Standard	665-66-7	200mg	$435	2026-04-30	Buy

Product number	Packaging	Price	Buy
A1260	5g	$72.7	Buy
BP530	200MG	$282	Buy
A0363000	100 mg	$175	Buy
8.20015	10g	$72.3	Buy
1018505	200mg	$435	Buy

Amantadine Hcl Chemical Properties, Uses, Production

Description

Amantadine Hcl is in a class of medications called adamantanes. It is thought to work to control movement problems by increasing the amount of dopamine in certain parts of the body. It works against influenza A virus by stopping the spread of the virus in the body. Amantadine is used to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions.

Uses

Amantadine Hcl is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantadine is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

Side effects

Blurred vision, nausea, stomach upset, drowsiness, dizziness, headache, dry mouth, constipation, nervousness, or trouble sleeping may occur.

Amantadine Hcl synthesis

Synthesis of Amantadine Hcl from Amantadine

Amantadine Hcl Preparation Products And Raw materials

Raw materials

Aluminium-nickel Amantadine Dicyclopentadiene Sodium sulfite Chlorine

Urea Aluminum chloride Hydrochloric acid Hydrogen Bromine

Sodium hydroxide Hydrogen cyanide Adamantane 2-Adamantanamine hydrochloride

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Preparation Products

Amantadine Hcl Suppliers

Global Suppliers ( 698)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Shengbang Biotechnology Co., Ltd.	13685312009	418162321@qq.com	China	60	58
Sichuan Zhongbang Pharma CO.，LTD	0830-0830-2585019 13679670161	sales2@zhongbangst.com	China	105	69
TIANJIN MINXIANG BIOMEDICAL INC.	13313219033	tjmx@mxpharm.com	China	39	58
Huzhou Chenxi Environmental Protection Technology Co., Ltd.	16762203950 16762203950	3775386035@qq.com	China	102	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Jinan Shengbang Biotechnology Co., Ltd.	58
Sichuan Zhongbang Pharma CO.，LTD	69
TIANJIN MINXIANG BIOMEDICAL INC.	58
Huzhou Chenxi Environmental Protection Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

1-Adamantanamine hydrochloride:an antiviral substance
1-Adamantanamine hydrochloride is a synthetic organic compound with highly soluble, relatively non-toxic, and biologically sta....
Nov 16,2023

View Latest Price from Amantadine Hcl manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	Amantadine 768-94-5		1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-01	Amantadine HCl 665-66-7		1kg	99%	1000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2026-05-28	Amantadine 281-23-2	$10.70	10kg	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

Amantadine
768-94-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Amantadine HCl
665-66-7
$0.00
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Amantadine
281-23-2
$10.70
99%
Hebei Chuanghai Biotechnology Co,.LTD

1-Adamantanamine hydrochloride Spectrum

1-Adamantanamine hydrochloride(665-66-7)MS 1-Adamantanamine hydrochloride(665-66-7)¹HNMR 1-Adamantanamine hydrochloride(665-66-7)¹³CNMR 1-Adamantanamine hydrochloride(665-66-7)IR1 1-Adamantanamine hydrochloride(665-66-7)IR2 1-Adamantanamine hydrochloride(665-66-7)Raman

665-66-7 (Amantadine Hcl) Related Search:

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Amantadine hydrochloride,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride Amantadine Hydrochloride (200 mg) 1-AdaMantanaMine hydrochloride, 99+% 100GR 1-AdaMantanaMine hydrochloride, 99+% 25GR 1-AdaMantanaMine hydrochloride, 99+% 5GR 1-adamantane amine hydrochloride 1-Adamantanamine Hydrochleride 1-Aminoadamantane Hydrochloride Amantadine Hydrochloride Adamantan-1-amine hydrochloride, Tricyclo[3.3.1.1~3,7~]decan-1-amine hydrochloride, Amantadine hydrochloride AMantadine HCl USP 1-adamantylammonium chloride 1-adamantylazanium chloride 1-Aminoadamantene hydrochlorid adamantan-1-aminium chloride tricyclo[3.3.1.1(3,7)]decan-1-aminium chloride Tricyclo[3.3.1.13,7]decan-1-amine, hydrochloride (1:1) aminoadamantanehydrochloride exp105-1 midantane mydantane nsc83653 symmetrel tricyclo(3.3.1.1(sup3,7))decan-1-amine,hydrochloride 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, Amantadine hydrochloride 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride 1-Adamantanamine HydrochL 1-adamantylammonium Adamantane Hydrocloride 1-Adamantanamine hydrochloride intermediate 1-Adamantanamine Hydrochloride [Amantadine Hydrochloride] Amintadine Hcl TIMTEC-BB SBB003680 TRICYCLODECANE HYDROCHLORIDE 1-aminoadamantenehydrochloride 1-ADAMANTYLAMINE HYDROCHLORIDE 1-ADAMANTANAMINE HCL 1-ADAMANTANAMINE HYDROCHLORIDE 1-ADAMANTANEAMMONIUM CHLORIDE 1-AMINOADAMANTANE HYDROCHLORIDE adamantinehydrochloride adamantylaminehydrochloride tricyclo[3.3.1.13,7]decan-1-amine,hydrochloride virasol AMANTADINE HYDROCHLORIDE, PHARMA Adekin Lysovir Mantadan Mantadix Virofral AMANTADINEHYDROCHLORIDE,USP 1-Adamantamine hydrochloride 1-Adamantanamine, hydrochloride (8CI) Adamantanamine hydrochloride (6CI) Amazolon Midantan 1-ADAMANTANAMINE HYDROCHLORIDE, 99+% 1-Adamantaneammonium chloride for synthesis 1-Adamantanamin Hydrochlorid