Diethyl ketomalonate
- CAS No.
- 609-09-6
- Chemical Name:
- Diethyl ketomalonate
- Synonyms
- Diethyl 2-oxomalonate;DIETHYL MESOXALATE;diethyl 2-oxopropanedioate;1,3-diethyl 2-oxopropanedioate;Propanedioic acid, oxo-, diethyl ester;ketomaL;Keto Malonate;Ethyl mesoxalate;ETHYL OXOMALONATE;DIETHYL MESOXYLATE
- CBNumber:
- CB0224840
- Molecular Formula:
- C7H10O5
- Molecular Weight:
- 174.15
- MDL Number:
- MFCD00009121
- MOL File:
- 609-09-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Diethyl ketomalonate 95% | D97401 | 5g | $62.1 |
| Diethyl ketomalonate 95% | D97401 | 25g | $204 |
| Diethyl Mesoxalate >94.0%(GC) | M0866 | 5g | $58 |
| Diethyl Mesoxalate >94.0%(GC) | M0866 | 25g | $228 |
| Diethyl Ketomalonate | TRC-D476633-500MG | 500mg | $96 |
| More product size | |||
| Melting point | -70°C |
|---|---|
| Boiling point | 208-210 °C (lit.) |
| Density | 1.142 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol |
| form | liquid |
| color | green-yellow |
| Specific Gravity | 1.142 |
| Water Solubility | Fully miscible with water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,5913 |
| BRN | 971873 |
| InChI | 1S/C7H10O5/c1-3-11-6(9)5(8)7(10)12-4-2/h3-4H2,1-2H3 |
| InChIKey | DBKKFIIYQGGHJO-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C(=O)C(=O)OCC |
| CAS DataBase Reference | 609-09-6(CAS DataBase Reference) |
| FDA UNII | H28C8N13IK |
| NIST Chemistry Reference | Propanedioic acid, oxo-, diethyl ester(609-09-6) |
| EPA Substance Registry System | Propanedioic acid, oxo-, diethyl ester (609-09-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 21 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT, MOISTURE SENSITIVE | |||||||||
| HS Code | 29183000 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
Diethyl ketomalonate price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D97401 | Diethyl ketomalonate 95% | 609-09-6 | 5g | $62.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | D97401 | Diethyl ketomalonate 95% | 609-09-6 | 25g | $204 | 2026-04-30 | Buy |
| TCI Chemical | M0866 | Diethyl Mesoxalate >94.0%(GC) | 609-09-6 | 5g | $58 | 2026-04-30 | Buy |
| TCI Chemical | M0866 | Diethyl Mesoxalate >94.0%(GC) | 609-09-6 | 25g | $228 | 2026-04-30 | Buy |
| TRC | TRC-D476633-500MG | Diethyl Ketomalonate | 609-09-6 | 500mg | $96 | 2026-06-03 | Buy |
Diethyl ketomalonate Chemical Properties,Uses,Production
Chemical Properties
Clear yellow liquid
Uses
Diethyl ketomalonate, reagent employed in Wittig and Aza-Wittig reactions for synthesis of triazoles, and 2-azadienes, respectively.
Application
Diethyl ketomalonate can be used in electron-deficient heterodienophile; Diels-Alder reaction; heterodipolarophile; [3 + 2] cycloaddition; 1,3-diyl trapping agent; 1,4-dipolar cycloaddition; [2 + 2] cycloaddition; enophile; ene reaction; electrophilic addition; Wittig reactions; condensation with amines; Pictet-Spengler reactions.
Preparation
Diethyl ketomalonate can be prepared by bromination of Diethyl Malonate to the dibromomalonic ester, exchange of one bromine atom for acetate and α-elimination of acetyl bromide. Alternatively, diethyl malonate is condensed with benzaldehyde to afford the Knoevenagel product which is cleaved by ozonolysis.
Synthesis Reference(s)
Synthetic Communications, 24, p. 695, 1994 DOI: 10.1080/00397919408012648
The Journal of Organic Chemistry, 46, p. 2598, 1981 DOI: 10.1021/jo00325a039
Synthesis
3377-20-6
609-09-6
The general procedure for the synthesis of diethyl ketomalonate from diethyl methylidenemalonate was as follows: 258 g of diethyl methylidenemalonate prepared by Knoevenagel condensation reaction of malonic acid and formaldehyde was dissolved in 1 liter of methanol, followed by ozonation reaction. Upon completion of the reaction, 5 g of 10% Pd-on-C was added as a hydrogenation catalyst and placed in 200 ml of methanol to carry out the hydrogenation reaction, with a hydrogen consumption of 28.9 standard liters (86% of the theoretical value was reached). The reaction mixture was post-treated according to the method of Example 5 and subsequently concentrated under vacuum to give 214 g of diethyl ketomalonate with a boiling point of 10.0-112°C/20 mmHg in 82% yield of the theoretical value.
storage
Diethyl ketomalonate is stable for at least 6 months if stored in the refrigerator.
References
[1] Patent: US4769464, 1988, A
[2] Tetrahedron Letters, 1981, vol. 22, # 46, p. 4607 - 4610
Diethyl ketomalonate Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8898 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9984 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15051 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
View Lastest Price from Diethyl ketomalonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Diethyl ketomalonate
609-09-6
|
$10.00 | 1KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2022-02-19 | Diethyl ketomalonate
609-09-6
|
1KG | 98.7% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | Diethyl ketomalonate
609-09-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Diethyl ketomalonate
609-09-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Diethyl ketomalonate
609-09-6
- $0.00
- 98.7%
- Honest Joy Holdings Limited
-
- Diethyl ketomalonate
609-09-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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