5-Bromo-2-fluoropyridine
- CAS No.
- 766-11-0
- Chemical Name:
- 5-Bromo-2-fluoropyridine
- Synonyms
- 5-BROMO-2-FLUOROPYRIDINE;5-Brom-2-fluorpyridin;3-BROMO-6-FLUOROPYRIDINE;5-BROMO-2-FLUO;2-Fluoro-5-bromopyri;2-FLUORO-5-BORMOPYRIDINE;3-fluoro-5-bromopyridine;2-Floro-5-Bromo Pyridine;2-FLUORO-5-BROMO PYRIDINE;5-Bromo-2-fluoropyridine>
- CBNumber:
- CB0344067
- Molecular Formula:
- C5H3BrFN
- Molecular Weight:
- 175.99
- MDL Number:
- MFCD01863742
- MOL File:
- 766-11-0.mol
- MSDS File:
- SDS
| Boiling point | 162-164 °C750 mm Hg(lit.) |
|---|---|
| Density | 1.71 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 165 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | -2.79±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless yellow |
| Specific Gravity | 1.710 |
| BRN | 1363171 |
| InChI | InChI=1S/C5H3BrFN/c6-4-1-2-5(7)8-3-4/h1-3H |
| InChIKey | MYUQKYGWKHTRPG-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C(Br)C=C1 |
| CAS DataBase Reference | 766-11-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37-37/39 | |||||||||
| RIDADR | UN2810 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
5-Bromo-2-fluoropyridine price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 520438 | 5-Bromo-2-fluoropyridine 99% | 766-11-0 | 5g | $34.3 | 2026-04-30 | Buy |
| TCI Chemical | B2705 | 5-Bromo-2-fluoropyridine >98.0%(GC) | 766-11-0 | 5g | $58 | 2026-04-30 | Buy |
| TCI Chemical | B2705 | 5-Bromo-2-fluoropyridine >98.0%(GC) | 766-11-0 | 25g | $192 | 2026-04-30 | Buy |
| Usbiological | 261712 | 5-Bromo-2-fluoropyridine Asreported | 766-11-0 | 50g | $333 | 2026-06-03 | Buy |
| Usbiological | 261712 | 5-Bromo-2-fluoropyridine Asreported | 766-11-0 | 100g | $446 | 2026-06-03 | Buy |
5-Bromo-2-fluoropyridine Chemical Properties,Uses,Production
Description
5-Bromo-2-fluoropyridine is a halogenated pyridine that has been used as a molecular scaffold for many Active Pharmaceutical Ingredients (APIs) such as Neuropeptide Y Receptor Y5 Inhibitors, SARS-CoV-2 Major Protease Inhibitors, and Indoleamine-2,3-Dioxygenase-1 Inhibitors in cancer immunotherapy. 5-Bromo-2-fluoropyridine is also an ideal building block for semiconductors, due to its aromaticity and electron deficiency. A host material of 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5H-benzo[d]benzo-[4,5]imidazo[1,2-a]imidazole is synthesized from 5-bromo-2-fluoropyridine for OLED applications.
Chemical Properties
5-Bromo-2-fluoropyridine is a colourless or yellowish liquid compound with a density of 1.71 g/cm3 at 25° C; boiling point of 162-164° C (lit.) at 750 mmHg; stored at room temperature.
Uses
5-Bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.
Synthesis
403-45-2
766-11-0
A. Synthesis of 2-fluoro-5-bromopyridine: 2.2 g (15.6 mmol) of 6-fluoronicotinic acid, 5.1 g of red mercuric oxide (HgO) and 1.2 ml of bromine were dissolved in 100 ml of carbon tetrachloride (CCl4) to form a suspension. The reaction was carried out under reflux conditions for 5 hours and subsequently cooled to room temperature. The reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under vacuum. The residue was dissolved in hexane, filtered again and the filtrate was concentrated under vacuum to give 1.73 g (63% yield) of 2-fluoro-5-bromopyridine, the product being a light yellow oil.
References
[1] Patent: US5618821, 1997, A
5-Bromo-2-fluoropyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing DeLee Pharma Technology Co.,Ltd. | 17316103847 | sales@deleepharma.com | China | 234 | 58 |
| JIANGYIN RUISHIPHARM CO.,LIMITED | 0510-0510-66227179 18921203887 | sales@ruishipharm.com | China | 747 | 58 |
| Shanghai Qiao Chemical Science Co., Ltd | 021-58892003 | info@qiaochem.com | China | 6065 | 65 |
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1340 | 58 |
| Ningbo Fuhe Chemical Co., Ltd. | 0574-1806900 18069001216 | nbfjj@126.com | China | 99 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
View Lastest Price from 5-Bromo-2-fluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 5-Bromo-2-fluoropyridine
766-11-0
|
1kg | 98% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 5-Brom-2-fluorpyridin
766-11-0
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Fluoro-5-bromopyridine
766-11-0
|
$1.10 | 1g | 99.0% Min | 100 Tons Min | Dideu Industries Group Limited |
-
- 5-Bromo-2-fluoropyridine
766-11-0
- 98%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-Brom-2-fluorpyridin
766-11-0
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoro-5-bromopyridine
766-11-0
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
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