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5-Bromo-2-nitropyridine

5-Bromo-2-nitropyridine structure

CAS No.: 39856-50-3

Chemical Name:: 5-Bromo-2-nitropyridine

Synonyms: 2-NITRO-5-BROMOPYRIDINE;AKOS BBS-00001330;5-Bromo-2-nitropyrid;Risdiplam Impurity 8;3-BROMO-6-NITROPYRIDINE;5-BROMO-2-NITROPYRIDINE;5-Bromo-2-notropyridine;2-Nitro-5-borMopyridine;Palbociclib impurity A;Pyridine, 5-broMo-2-nitro-

CBNumber:: CB1773370

Molecular Formula:: C5H3BrN2O2

Molecular Weight:: 202.99

MDL Number:: MFCD00160411

MOL File:: 39856-50-3.mol

MSDS File:: SDS

Last updated:2025-09-09 10:27:52

Product description	Number	Pack Size	Price
5-Bromo-2-nitropyridine 99%	520411	5g	$48.78
5-Bromo-2-nitropyridine >98.0%(GC)	B2766	1g	$20
5-Bromo-2-nitropyridine >98.0%(GC)	B2766	5g	$57
5-Bromo-2-nitropyridine	B686180	1g	$45
2-NITRO-5-BROMO PYRIDINE 95.00%	HCH0020190	5G	$782.76
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5-Bromo-2-nitropyridine Properties

Melting point	148-150 °C (lit.)
Boiling point	292.3±20.0 °C(Predicted)
Density	1.833±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-4.95±0.22(Predicted)
color	White to yellow to beige powder or crystal or chunks
BRN	120878
InChI	InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
InChIKey	ATXXLNCPVSUCNK-UHFFFAOYSA-N
SMILES	C1([N+]([O-])=O)=NC=C(Br)C=C1
CAS DataBase Reference	39856-50-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

HazardClass

IRRITANT

PackingGroup

III

HS Code

29339900

NFPA 704

	1
2		0

5-Bromo-2-nitropyridine price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	520411	5-Bromo-2-nitropyridine 99%	39856-50-3	5g	$48.78	2025-07-31	Buy
TCI Chemical	B2766	5-Bromo-2-nitropyridine >98.0%(GC)	39856-50-3	1g	$20	2025-07-31	Buy
TCI Chemical	B2766	5-Bromo-2-nitropyridine >98.0%(GC)	39856-50-3	5g	$57	2025-07-31	Buy
TRC	B686180	5-Bromo-2-nitropyridine	39856-50-3	1g	$45	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0020190	2-NITRO-5-BROMO PYRIDINE 95.00%	39856-50-3	5G	$782.76	2021-12-16	Buy

Product number	Packaging	Price	Buy
520411	5g	$48.78	Buy
B2766	1g	$20	Buy
B2766	5g	$57	Buy
B686180	1g	$45	Buy
HCH0020190	5G	$782.76	Buy

5-Bromo-2-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

Colorless solid

Uses

5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.

Preparation

5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].

Synthesis Reference(s)

[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.

Synthesis

1072-97-5

39856-50-3

General steps for the synthesis of 5-bromo-2-nitropyridine from 2-amino-5-bromopyridine: Add 500L of glacial acetic acid and 150L of acetic acid in a 1000L autoclave, turn on the stirring and circulate the cooling water. When the mixture is homogeneous, slowly add 120 kg of 2-amino-5-bromopyridine and control the temperature at 20℃. After stirring for 30 minutes, 300 kg of peroxyacetic acid was slowly added dropwise. When the dropwise addition to the remaining about 50kg, observed that the temperature began to rise slowly, at this time to suspend the dropwise addition. After the temperature stabilized and stopped rising, the remaining peroxyacetic acid was added dropwise, and the temperature was kept at 30℃ throughout the process. After the dropwise addition was completed, the temperature was raised to 40°C and the reaction was kept at a constant temperature for 20 hours. After the reaction was completed, distillation was carried out under reduced pressure, and the distillation was stopped after about 600 L of acetic acid was evaporated. The remaining liquid was cooled to 25 °C, diluted by adding 500 L of water, and the pH was adjusted with 40% sodium hydroxide solution to 8. Subsequently, the mixture was cooled to -20 °C, filtered and dried to give 125 kg of crude product in 89.3% yield. After recrystallization, 120.5 kg of pure product was obtained in 86.1% yield.

References

[1] Patent: CN106187867, 2016, A. Location in patent: Paragraph 0035; 0044; 0045
[2] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 3, p. 467 - 479
[3] Patent: CN108558745, 2018, A. Location in patent: Paragraph 0023; 0024; 0025; 0026
[4] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 113
[5] Journal of Organic Chemistry, 2008, vol. 73, # 23, p. 9326 - 9333

5-Bromo-2-nitropyridine synthesis

Synthesis of 5-Bromo-2-nitropyridine from 2-Amino-5-bromopyridine

5-Bromo-2-nitropyridine Preparation Products And Raw materials

Raw materials

5-Bromo-2-pyridinecarboxylic Acid 3-BROMOPYRIDINE-N-OXIDE 3-BROMO-4-NITROPYRIDINE N-OXIDE 2-Aminopyridine 2-Amino-5-bromopyridine

3-Pyridyl bromide

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Preparation Products

3,5-Dibromo-2-pyridylamine 1533432-50-6 ethyl 2-(6-aminopyridin-3-yl)acetate 1-(6-nitropyridin-3-yl)piperazine 5-HYDROXY-2-NITROPYRIDINE

1-(6-Nitropyridin-3-yl)pyrrolidin-2-one

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5-Bromo-2-nitropyridine Suppliers

Global( 634)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Fullone Chemical Co., Ltd.	+86-13328197671 +86-13861172460	sales@borenchem.cn	China	1055	58
Wuhan BJM Pharm Inc	027-52341919 13545198479	sales03@benjaminpharmchem.com	China	585	58
Beijing Wisdom Chemicals Co., Ltd.	+8613701363759	market@wisdomchem.com	China	254	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
hebei hongtan Biotechnology Co., Ltd	+852-6619 3215 +86-17731935328	sales03@chemcn.cn	China	970	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55

Supplier	Advantage
Changzhou Fullone Chemical Co., Ltd.	58
Wuhan BJM Pharm Inc	58
Beijing Wisdom Chemicals Co., Ltd.	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55

View Lastest Price from 5-Bromo-2-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	5-Bromo-2-nitropyridine 39856-50-3	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-10-17	5-Bromo-2-nitropyridine 39856-50-3	US $0.00 / gm	100gm	99%min	100kgs	Shanghai Yongzeng Technology Co.,Ltd
2025-09-25	5-Bromo-2-nitropyridine 39856-50-3	US $31.00-1.20 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

5-Bromo-2-nitropyridine
39856-50-3
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

5-Bromo-2-nitropyridine
39856-50-3
US $0.00 / gm
99%min
Shanghai Yongzeng Technology Co.,Ltd

5-Bromo-2-nitropyridine
39856-50-3
US $31.00-1.20 / kg
99%
Henan Fengda Chemical Co., Ltd

5-Bromo-2-nitropyridine Spectrum

5-Bromo-2-nitropyridine(39856-50-3)MS 5-Bromo-2-nitropyridine(39856-50-3)¹HNMR 5-Bromo-2-nitropyridine(39856-50-3)IR1 5-Bromo-2-nitropyridine(39856-50-3)IR2

39856-50-3(5-Bromo-2-nitropyridine)Related Search:

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3,5-DIBROMO-4-NITROPYRIDINE 2-CHLORO-3-BROMO-5-NITROPYRIDINE 4-AMINO-3-BROMO-5-NITROPYRIDINE 2,6-Dibromo-3-nitropyridine 4-BROMO-3-NITROPYRIDINE

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AKOS BBS-00001330 2-NITRO-5-BROMOPYRIDINE 5-BROMO-2-NITROPYRIDINE 3-BROMO-6-NITROPYRIDINE 2-NITRO-5-BROMO PYRIDINE(5-BROMO-2-NITROPYRIDINE) 5-BROMO-2-NITROPYRIDINE, 98+% 3-Bromo-6-nitropyridine (5-Bromo-2-nitropyridine) 5-Bromo-2-notropyridine 5-Bromo-2-nitropyrid 5-BroMo-2-nitropyridine, 99% 1GR Pyridine, 5-broMo-2-nitro- 2-Nitro-5-borMopyridine 2-Nitro-5-broMopyridine, 98%, 98% 2 - nitro - 5 - broMide pyridine Palbociclib impurity A 5-Bromo-2-nitropyridine 99% 5-Bromo-2-nitropyridine > 5-Bromo-2-nitropyridine ISO 9001：2015 REACH 39856-50-3 5-Bromo-2-nitropyridine 5-BROMO-2-NITROPYRIDINE Extra Pure 5-Bromo-2-nitropyridine, 95% Risdiplam Impurity 8 39856-50-3 39586-50-3 2-NITRO-5-BROMO 851607-56-6 C5H3N2O2Br Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Bromopyridines Halopyridines Building Blocks Heterocycle-Pyridine series blocks Bromides Pyridines Pyridine Pyridines, Pyrimidines, Purines and Pteredines Organohalides Bromopyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines derivates 39856-50-3