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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE structure

CAS No.: 72537-17-8

Chemical Name:: 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

Synonyms: 2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-;3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%;TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH

CBNumber:: CB2145237

Molecular Formula:: C6H2ClF4N

Molecular Weight:: 199.53

MDL Number:: MFCD00191918

MOL File:: 72537-17-8.mol

MSDS File:: SDS

Last updated:2026-05-28 00:05:33

Product description	Number	Pack Size	Price
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%	393576	5g	$105
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98.0%(GC)	C2671	5g	$58
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98%	PC4375	5g	$21
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98%	PC4375	25g	$37
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98%	PC4375	100g	$138
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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Properties

Melting point	16-20 °C (lit.)
Boiling point	50-55 °C/11 mmHg (lit.)
Density	1.524 g/mL at 25 °C (lit.)
refractive index	n20/D 1.433(lit.)
Flash point	125 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Liquid
color	Colorless
InChI	InChI=1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
InChIKey	GDSROTVTTLUHCO-UHFFFAOYSA-N
SMILES	C1(F)=NC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference	72537-17-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

10-36/37/38

Safety Statements

26-36

RIDADR

UN 1993 3/PG 3

WGK Germany

Hazard Note

Irritant

HazardClass

3.2

PackingGroup

III

HS Code

29333990

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	393576	3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%	72537-17-8	5g	$105	2023-01-07	Buy
TCI Chemical	C2671	3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98.0%(GC)	72537-17-8	5g	$58	2026-04-30	Buy
Apolloscientific	PC4375	3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98%	72537-17-8	5g	$21	2026-06-04	Buy
Apolloscientific	PC4375	3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98%	72537-17-8	25g	$37	2026-06-04	Buy
Apolloscientific	PC4375	3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98%	72537-17-8	100g	$138	2026-06-04	Buy

Product number	Packaging	Price	Buy
393576	5g	$105	Buy
C2671	5g	$58	Buy
PC4375	5g	$21	Buy
PC4375	25g	$37	Buy
PC4375	100g	$138	Buy

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Uses,Production

Uses

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.

General Description

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.

Synthesis

2,3-Dichloro-5-(trifluoromethyl)pyridine

69045-84-7

72537-17-8

The general procedure for the synthesis of 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: Example 3b. Equipment: 250 mL four-necked round-bottomed flask equipped with a thermometer, mechanical stirrer, dropping funnel and inert gas inlet. Operating steps: 1. 25 mL of DMSO was added to a 250 mL four-necked round-bottomed flask, and the solvent was evaporated from a suspension of 150 mL of DMSO, 2.5 g of potassium carbonate (17.9 mmol), and 25.0 g of cesium fluoride (162.9 mmol) at 120 °C and 25-30 mbar pressure. 2. 25.0 g of 2,3-dichloro-5-trifluoromethylpyridine (112.3 mmol) was added to the reaction mixture and the reaction was stirred at 120 °C for 4 hours. 3. After completion of the reaction, the suspension was filtered and the product 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine was distilled directly from the distillate at 95 to 115 °C and 40-60 mbar pressure to obtain the product in quantitative yield. PRODUCT ANALYSIS: GC analysis showed a product purity of 96.9 area percent.

References

[1] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 9-10
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6
[3] Patent: CN107286087, 2017, A. Location in patent: Paragraph 0032; 0033
[4] Patent: CN106905231, 2017, A. Location in patent: Paragraph 0077; 0078; 0079; 0080; 0081; 0082; 0083-0085
[5] Patent: EP1199305, 2002, A1. Location in patent: Page 6

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

2,3-Dichloro-5-(trichloromethyl)pyridine 2,3-Dichloro-5-(trifluoromethyl)pyridine Dimethyl sulfoxide Caesium fluoride Potassium carbonate

Preparation Products

Methyl 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoate 2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine 3-Chloro-5-(trifluoromethyl)pyridine Succinonitrile

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Suppliers

Global( 216)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Jihui Chemical Co., Ltd.	+86-15053042019	sales@jihuichem.com	China	34	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1444	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
Zhengzhou Alfa Chemical Co.,Ltd	+86-18530059196	sale04@alfachem.cn	China	9674	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
Shanghai UCHEM Inc.	+86-18930848214 +86-021-56762820	sales@myuchem.com	China	8926	58

Supplier	Advantage
Shandong Jihui Chemical Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58
Career Henan Chemica Co	58
Shanghai UCHEM Inc.	58

View Lastest Price from 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-02-28	2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine 72537-17-8		250KG	Purity: 99%	1000tons	Shandong Jihui Chemical Co., Ltd.
2019-07-06	3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8	$1.00	1KG	98%	1kg,5kg,100kg	Career Henan Chemical Co

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
72537-17-8
$1.10
99.00%
Dideu Industries Group Limited

2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8
Purity: 99%
Shandong Jihui Chemical Co., Ltd.

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
72537-17-8
$1.00
98%
Career Henan Chemical Co

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Spectrum

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE(72537-17-8)¹HNMR 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE(72537-17-8)IR 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE(72537-17-8)Raman

72537-17-8(3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE)Related Search:

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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98% 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine > Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8 71537-17-8 C6H2ClF4N Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Halogenated Heterocycles Heterocyclic Building Blocks Pyridines, Pyrimidines, Purines and Pteredines Halides Pyridines C6Heterocyclic Building Blocks