2-Fluoro-5-trifluoromethylpyridine
- CAS No.
- 69045-82-5
- Chemical Name:
- 2-Fluoro-5-trifluoromethylpyridine
- Synonyms
- 2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;uoro-6-(trifL;2-Fluoro-5-(Trichloromethyl)Py;Pyridine, 2-fluoro-5-(trifluoroMethyl)-;2-Fluoro-5-(trifluoromethyl)pyridine>2-Fluoro-5-(trifluoromethyl)pyridine 97%;2-Fluoro-5-(trifluoromethyl)pyridine ,98%;2-Fluoro-5-trifluoromethylpyridine ISO 9001：2015 REACH
- CBNumber:
- CB9299728
- Molecular Formula:
- C6H3F4N
- Molecular Weight:
- 165.09
- MDL Number:
- MFCD07437945
- MOL File:
- 69045-82-5.mol
- MSDS File:
- SDS
| Boiling point | 118-122℃ |
|---|---|
| Density | 1.368 g/mL at 25 °C |
| Flash point | 35°(95°F) |
| refractive index | 1.4020 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -2.86±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| InChI | InChI=1S/C6H3F4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H |
| InChIKey | UUODQIKUTGWMPT-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C(C(F)(F)F)C=C1 |
| CAS DataBase Reference | 69045-82-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H317-H412-H402 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P261-P272-P302+P352+P333+P313+P363-P403+P235-P501-P280a-P303+P361+P353-P501a-P273-P280 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-52/53-43-10 | |||||||||
| Safety Statements | 26-36/37/39-45-61-37-24-36-27 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Aquatic Chronic 3 Flam. Liq. 3 Skin Sens. 1 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
2-Fluoro-5-trifluoromethylpyridine price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0846 | 2-Fluoro-5-(trifluoromethyl)pyridine >98.0%(GC) | 69045-82-5 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | F0846 | 2-Fluoro-5-(trifluoromethyl)pyridine >98.0%(GC) | 69045-82-5 | 5g | $36 | 2026-04-30 | Buy |
| Apolloscientific | PC4374 | 2-Fluoro-5-(trifluoromethyl)pyridine 97% | 69045-82-5 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC4374 | 2-Fluoro-5-(trifluoromethyl)pyridine 97% | 69045-82-5 | 100g | $58 | 2026-06-04 | Buy |
| Activate Scientific | AS38616 | 2-Fluoro-5-(trifluoromethyl)pyridine 96% | 69045-82-5 | 5g | $17 | 2026-06-04 | Buy |
2-Fluoro-5-trifluoromethylpyridine Chemical Properties, Uses, Production
Application
2-Fluoro-5-trifluoromethylpyridine is an important chemical intermediate. By introducing fluorine atoms into the pyridine ring and pyridine side chain, it has strong lipophilicity and can play an important role in pesticides and pharmaceuticals. Its application value and market prospects are very promising.
Chemical Properties
Colorless liquid
Synthesis
In a 1-liter three-necked flask, 46.20g (0.80 mol) of KF was added, followed by 500 mL of N, N-dimethylacetamide, which was warmed to 125 °C and stirred for 30 minutes. The setup was then connected to a distillation unit for micro-vacuum distillation, during which fractions were collected, and the water content was monitored using three separate bottles. Distillation was halted when the water content reached less than 500 ppm. Subsequently, 7g (0.03 mol) of benzyl triethyl ammonium chloride and 100g (0.55 mol) of 2-chloro-5-trifluoromethylpyridine were added to the flask. A condenser was connected, and the mixture was warmed to 135 °C and stirred for 10 hours. Gas chromatography was used to monitor the reaction; the reaction was stopped when the content of 2-chloro-5-trifluoromethylpyridine in the reaction solution was less than 1%. The reaction solution was directly distilled under reduced pressure to collect the fraction at 40-45 °C / 11 mmHg, yielding 87.80g of 2-fluoro-5-trifluoromethylpyridine with a purity of 98.95% (GC) and a yield of 95.56%.
References
[1] Patent: CN106866509, 2017, A. Location in patent: Paragraph 0030; 0032; 0044; 0046
2-Fluoro-5-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 2-Fluoro-5-trifluoromethylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Fluoro-5-trifluoromethylpyridine
69045-82-5
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-02-28 | 2-Fluoro-5-(trifluoromethyl)pyridine
69045-82-5
|
250kg | Purity: 99% | 1000tons | Shandong Jihui Chemical Co., Ltd. | ||
 |
2021-10-16 | 2-Fluoro-5-trifluoromethylpyridine
69045-82-5
|
$10.00 | 1KG | 99% | 20 TONS | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 2-Fluoro-5-trifluoromethylpyridine
69045-82-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Fluoro-5-(trifluoromethyl)pyridine
69045-82-5
- Purity: 99%
- Shandong Jihui Chemical Co., Ltd.
-
- 2-Fluoro-5-trifluoromethylpyridine
69045-82-5
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
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