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3-Chloro-4-cyanopyridine

3-Chloro-4-cyanopyridine structure

CAS No.: 68325-15-5

Chemical Name:: 3-Chloro-4-cyanopyridine

Synonyms: 3-CHLORO-ISONICOTINONITRILE;3-Chloro-4-cyanopyri;3-chloro-4-cynopyridine;3-CHLORO-4-CYANOPYRIDINE;3- chloro-4-cyanpyridine;3-Chloro-4-cyanopyridine ,98%;3-Chloropyridin-4-carbonitrile;3-CHLOROPYRIDINE-4-CARBONITRILE;3-Chloro-4-pyridinecarbonitrile;4-Pyridinecarbonitrile, 3-chloro-

CBNumber:: CB2209702

Molecular Formula:: C6H3ClN2

Molecular Weight:: 138.55

MDL Number:: MFCD05663706

MOL File:: 68325-15-5.mol

MSDS File:: SDS

Last updated:2026-01-13 11:18:00

Product description	Number	Pack Size	Price
3-Chloropyridine-4-carbonitrile 97%	792667	500mg	$140
3-Chloro-4-cyanopyridine >98.0%(GC)	C2998	1g	$42
3-Chloro-4-cyanopyridine >98.0%(GC)	C2998	5g	$164
3-Chloro-4-cyanopyridine	C4978-45	100mg	$403
3-Chloro-4-cyanopyridine	C365100	500mg	$495
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3-Chloro-4-cyanopyridine Properties

Melting point	71-73°C
Boiling point	233.3±20.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Dichloromethane, Ethyl Acetate, Methanol
form	Solid
pka	-0.41±0.18(Predicted)
color	Pale Yellow
InChI	InChI=1S/C6H3ClN2/c7-6-4-9-2-1-5(6)3-8/h1-2,4H
InChIKey	JLLJPPBGJVCFGG-UHFFFAOYSA-N
SMILES	C1=NC=CC(C#N)=C1Cl
CAS DataBase Reference	68325-15-5(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P301+P310-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36/37

RIDADR

UN3439

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29333990

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

3-Chloro-4-cyanopyridine price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	792667	3-Chloropyridine-4-carbonitrile 97%	68325-15-5	500mg	$140	2023-01-07	Buy
TCI Chemical	C2998	3-Chloro-4-cyanopyridine >98.0%(GC)	68325-15-5	1g	$42	2025-07-31	Buy
TCI Chemical	C2998	3-Chloro-4-cyanopyridine >98.0%(GC)	68325-15-5	5g	$164	2025-07-31	Buy
Usbiological	C4978-45	3-Chloro-4-cyanopyridine	68325-15-5	100mg	$403	2021-12-16	Buy
TRC	C365100	3-Chloro-4-cyanopyridine	68325-15-5	500mg	$495	2021-12-16	Buy

Product number	Packaging	Price	Buy
792667	500mg	$140	Buy
C2998	1g	$42	Buy
C2998	5g	$164	Buy
C4978-45	100mg	$403	Buy
C365100	500mg	$495	Buy

3-Chloro-4-cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.

Synthesis

100-48-1

68325-15-5

The general procedure for the synthesis of 3-chloro-4-cyanopyridine from 4-cyanopyridine was as follows: to a stirred solution of 2,2,6,6-tetramethylpiperidine (17.16 mL, 100.854 mmol) in tetrahydrofuran (THF, 100 mL) at -30 °C was slowly added n-butyllithium (n-BuLi, 2.17 M, 44.26 mL, 96.052 mmol). The reaction mixture was stirred at 25 °C for 15 min before being cooled to -78 °C and a solution of 4-cyanopyridine (5 g, 48.026 mmol) in THF (40 mL) was added slowly and dropwise. After continued stirring at -78 °C for 30 min, a THF (50 mL) solution of hexaethyl ethane (23.87 g, 100.854 mmol) was added. The resulting mixture was stirred at -78 °C for 30 min, followed by quenching the reaction with saturated ammonium chloride (NH4Cl) solution. Water (100 mL) was added to the reaction mixture and extracted with ethyl acetate (4 x 300 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 5% ethyl acetate-hexane as eluent to yield 3-chloropyridine-4-carbonitrile (3.5 g, 25.26±1 mmol, 53% yield) as a light-white solid.The GC-MS analysis showed the molecular ion peak to be 138 m/z. The molecular ions were analyzed by GC-MS.

References

[1] Tetrahedron, 2006, vol. 62, # 25, p. 5862 - 5867
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10118 - 10129
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 182; 183
[4] Tetrahedron Letters, 2005, vol. 46, # 1, p. 135 - 137
[5] Journal of the American Chemical Society, 2013, vol. 135, # 24, p. 9213 - 9219

3-Chloro-4-cyanopyridine Preparation Products And Raw materials

Raw materials

Sodium perborate tetrahydrate 4-Cyanopyridine Hydrogen peroxide Phosphorus oxitrichloride Phosphorus pentachloride

Sodium bicarbonate Acetic acid 4-Cyanopyridine N-oxide Tetrahydrofuran Hexachloroethane

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Preparation Products

3-AMINO-4-CYANOPYRIDINE Thieno[2,3-c]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI) 3-(Benzyloxy)pyridine-4-carbonitrile 4-PYRIDINECARBONITRILE, 3-(METHYLTHIO)- Ethyl 3-aminothieno[2,3-c]pyridine-2-carboxylate

3-Chloro-4-cyanopyridine Suppliers

Global( 273)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 3-Chloro-4-cyanopyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-25	3-Chloro-4-cyanopyridine 68325-15-5	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2022-09-12	3-Chloro-4-cyanopyridine 68325-15-5	US $0.00-0.00 / G	1G	98%min	50kg/month	Shanghai Rlavie Technology Co ltd
2019-07-06	3-Chloro-4-cyanopyridine 68325-15-5	US $1.00 / kg	1kg	95%-99%	as request	Career Henan Chemical Co

3-Chloro-4-cyanopyridine
68325-15-5
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

3-Chloro-4-cyanopyridine
68325-15-5
US $0.00-0.00 / G
98%min
Shanghai Rlavie Technology Co ltd

3-Chloro-4-cyanopyridine
68325-15-5
US $1.00 / kg
95%-99%
Career Henan Chemical Co

3-Chloro-4-cyanopyridine Spectrum

3-Chloro-4-cyanopyridine(68325-15-5)¹HNMR 3-Chloro-4-cyanopyridine(68325-15-5)FT-IR

68325-15-5(3-Chloro-4-cyanopyridine)Related Search:

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2-AMINO-3-CHLORO-5-CYANOPYRIDINE, 95+% 3,5-Dichloro-2-cyanopyridine 2-CYANO-3-CHLORO PYRIDINE / 3-CHLORO-2-CYANOPYRIDINE,3-Chloro-2-cyanopyridine ,95%,3-CHLORO-2-CYANOPYRIDINE 2,6-Dichloroisonicotinonitrile P-1002-Chloro-6-Cyanopyridine,6-CHLORO-2-CYANOPYRIDINE,2-CHLORO-6-CYANOPYRIDINE

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3-CHLORO-4-CYANOPYRIDINE 3-CHLORO-ISONICOTINONITRILE 3-CHLOROPYRIDINE-4-CARBONITRILE 3-chloro-4-cynopyridine 4-Pyridinecarbonitrile,3-chloro-(9CI) 3-Chloro-4-cyanopyridine ,98% 3-Chloro-4-pyridinecarbonitrile 3-Chloro-4-cyanopyri 3-Chloro-4-cyanopyridine, 3-Chloropyridine-4-carbonitrile 3-Chloropyridine-4-carbonitrile 97% 3-Chloro-4-Cyanopyridine(WX683516) 3- chloro-4-cyanpyridine 4-Pyridinecarbonitrile, 3-chloro- 3-Chloro-4-cyanopyridine ISO 9001：2015 REACH 3-Chloropyridin-4-carbonitrile 68325-15-5 68325-15-3 C6H3ClN Amines NITRILE Halides Pyridines Heterocyclic Compounds Heterocycle-Pyridine series Aromatics Heterocycles Pyridine