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3-Chloro-4-cyanopyridine

3-Chloro-4-cyanopyridine Structure
3-Chloro-4-cyanopyridine structure
CAS No.
68325-15-5
Chemical Name:
3-Chloro-4-cyanopyridine
Synonyms
3-CHLOROPYRIDINE-4-CARBONITRILE;3-CHLORO-ISONICOTINONITRILE;3-Chloro-4-cyanopyri;3-chloro-4-cynopyridine;3- chloro-4-cyanpyridine;3-CHLORO-4-CYANOPYRIDINE;3-Chloro-4-cyanopyridine ,98%;3-Chloropyridin-4-carbonitrile;3-Chloro-4-pyridinecarbonitrile;4-Pyridinecarbonitrile, 3-chloro-
CBNumber:
CB2209702
Molecular Formula:
C6H3ClN2
Molecular Weight:
138.55
MDL Number:
MFCD05663706
MOL File:
68325-15-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-19 07:28:27
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3-Chloro-4-cyanopyridine Properties

Melting point 71-73°C
Boiling point 233.3±20.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Dichloromethane, Ethyl Acetate, Methanol
form Solid
pka -0.41±0.18(Predicted)
color Pale Yellow
InChI InChI=1S/C6H3ClN2/c7-6-4-9-2-1-5(6)3-8/h1-2,4H
InChIKey JLLJPPBGJVCFGG-UHFFFAOYSA-N
SMILES C1=NC=CC(C#N)=C1Cl
CAS DataBase Reference 68325-15-5(CAS DataBase Reference)
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P301+P310-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36/37
RIDADR  UN3439
WGK Germany  3
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29333990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 0

3-Chloro-4-cyanopyridine price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 792667 3-Chloropyridine-4-carbonitrile 97% 68325-15-5 500mg $140 2023-01-07 Buy
TCI Chemical C2998 3-Chloro-4-cyanopyridine >98.0%(GC) 68325-15-5 1g $37 2026-04-30 Buy
TCI Chemical C2998 3-Chloro-4-cyanopyridine >98.0%(GC) 68325-15-5 5g $145 2026-04-30 Buy
TRC TRC-C365100-500MG 3-Chloro-4-cyanopyridine 68325-15-5 500mg $669 2026-06-03 Buy
TRC TRC-C365100-1G 3-Chloro-4-cyanopyridine 68325-15-5 1g $1254 2026-06-03 Buy
Product number Packaging Price Buy
792667 500mg $140 Buy
C2998 1g $37 Buy
C2998 5g $145 Buy
TRC-C365100-500MG 500mg $669 Buy
TRC-C365100-1G 1g $1254 Buy

3-Chloro-4-cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.

Synthesis

4-Cyanopyridine

100-48-1

3-Chloro-4-cyanopyridine

68325-15-5

The general procedure for the synthesis of 3-chloro-4-cyanopyridine from 4-cyanopyridine was as follows: to a stirred solution of 2,2,6,6-tetramethylpiperidine (17.16 mL, 100.854 mmol) in tetrahydrofuran (THF, 100 mL) at -30 °C was slowly added n-butyllithium (n-BuLi, 2.17 M, 44.26 mL, 96.052 mmol). The reaction mixture was stirred at 25 °C for 15 min before being cooled to -78 °C and a solution of 4-cyanopyridine (5 g, 48.026 mmol) in THF (40 mL) was added slowly and dropwise. After continued stirring at -78 °C for 30 min, a THF (50 mL) solution of hexaethyl ethane (23.87 g, 100.854 mmol) was added. The resulting mixture was stirred at -78 °C for 30 min, followed by quenching the reaction with saturated ammonium chloride (NH4Cl) solution. Water (100 mL) was added to the reaction mixture and extracted with ethyl acetate (4 x 300 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 5% ethyl acetate-hexane as eluent to yield 3-chloropyridine-4-carbonitrile (3.5 g, 25.26±1 mmol, 53% yield) as a light-white solid.The GC-MS analysis showed the molecular ion peak to be 138 m/z. The molecular ions were analyzed by GC-MS.

References

[1] Tetrahedron, 2006, vol. 62, # 25, p. 5862 - 5867
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10118 - 10129
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 182; 183
[4] Tetrahedron Letters, 2005, vol. 46, # 1, p. 135 - 137
[5] Journal of the American Chemical Society, 2013, vol. 135, # 24, p. 9213 - 9219

3-Chloro-4-cyanopyridine Preparation Products And Raw materials

Raw materials

Sodium perborate tetrahydrate 4-Cyanopyridine Hydrogen peroxide Phosphorus oxitrichloride Phosphorus pentachloride
Sodium bicarbonate Acetic acid 4-Cyanopyridine N-oxide Tetrahydrofuran Hexachloroethane

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Preparation Products

3-AMINO-4-CYANOPYRIDINE Thieno[2,3-c]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI) 3-(Benzyloxy)pyridine-4-carbonitrile 4-PYRIDINECARBONITRILE, 3-(METHYLTHIO)- Ethyl 3-aminothieno[2,3-c]pyridine-2-carboxylate

3-Chloro-4-cyanopyridine Suppliers

Global( 279)Suppliers
Supplier Tel Email Country ProdList Advantage
TaiZhou ZhiCheng Chemicals & Technology Co., LTD. 0523-82837785 13914525028 info@jszchg.com China 244 60
Jiaxing Hengrui Biotechnology Co. LTD 0573-0573-82672231 13757365595 regen_chemical1@163.com China 4858 58
LinkChem Technology Co., Ltd. 58950110 13124863828 sales@linkchem.cn China 2993 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
TaiZhou ZhiCheng Chemicals & Technology Co., LTD. 60
Jiaxing Hengrui Biotechnology Co. LTD 58
LinkChem Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Energy Chemical 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66

View Lastest Price from 3-Chloro-4-cyanopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-4-cyanopyridine pictures 2026-06-30 3-Chloro-4-cyanopyridine
68325-15-5
 1kg 98% 10000kgS Shaanxi Dideu New Materials Co. Ltd
3-Chloro-4-cyanopyridine pictures 2025-06-25 3-Chloro-4-cyanopyridine
68325-15-5
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
3-Chloro-4-cyanopyridine pictures 2022-09-12 3-Chloro-4-cyanopyridine
68325-15-5
 1G 98%min 50kg/month Shanghai Rlavie Technology Co ltd

3-Chloro-4-cyanopyridine Spectrum

3-Chloro-4-cyanopyridine(68325-15-5)1HNMR3-Chloro-4-cyanopyridine(68325-15-5)FT-IR

68325-15-5(3-Chloro-4-cyanopyridine)Related Search:

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3-CHLORO-4-CYANOPYRIDINE 3-CHLORO-ISONICOTINONITRILE 3-chloro-4-cynopyridine 4-Pyridinecarbonitrile,3-chloro-(9CI) 3-Chloro-4-cyanopyridine ,98% 3-Chloro-4-pyridinecarbonitrile 3-Chloro-4-cyanopyri 3-Chloro-4-cyanopyridine, 3-Chloropyridine-4-carbonitrile 3-Chloropyridine-4-carbonitrile 97% 3-Chloro-4-Cyanopyridine(WX683516) 3- chloro-4-cyanpyridine 4-Pyridinecarbonitrile, 3-chloro- 3-Chloro-4-cyanopyridine ISO 9001：2015 REACH 3-Chloropyridin-4-carbonitrile 3-CHLOROPYRIDINE-4-CARBONITRILE 68325-15-5 68325-15-3 C6H3ClN Amines NITRILE Halides Pyridines Heterocyclic Compounds Heterocycle-Pyridine series Aromatics Heterocycles Pyridine