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3-Chloro-5-(trifluoromethyl)pyridin-2-amine

3-Chloro-5-(trifluoromethyl)pyridin-2-amine Structure
3-Chloro-5-(trifluoromethyl)pyridin-2-amine structure
CAS No.
79456-26-1
Chemical Name:
3-Chloro-5-(trifluoromethyl)pyridin-2-amine
Synonyms
2-AMINO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;ACTP;5-ACTF;2,3,5-actf;Compound Fr12847;TIMTEC-BB SBB003584;3-Chloro-5-(trifluor;LABOTEST-BB LT00012608;2-Amino-3-Chloro-5-Trifluorome;2-Amino-3-chloro-5-trifluoropyridine
CBNumber:
CB2331315
Molecular Formula:
C6H4ClF3N2
Molecular Weight:
196.56
MDL Number:
MFCD00042154
MOL File:
79456-26-1.mol
MSDS File:
SDS
Last updated:2026-05-28 00:20:28
Product description Number Pack Size Price
2-Amino-3-chloro-5-(trifluoromethyl)pyridine 97% 366080 25g $44.9
2-Amino-3-chloro-5-trifluoromethylpyridine >98.0%(GC) A1157 5g $38
2-Amino-3-chloro-5-trifluoromethylpyridine >98.0%(GC) A1157 25g $112
2-Amino-3-chloro-5-(trifluoromethyl)pyridine 97% 3H30-7-35 1kg $295
2-Amino-3-chloro-5-(trifluoromethyl)pyridine 98% A39238 1g $15
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3-Chloro-5-(trifluoromethyl)pyridin-2-amine Properties

Melting point 86-90 °C (lit.)
Boiling point 205°C
Density 1.4650 (estimate)
vapor pressure 40.8Pa at 24.85℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 1.79±0.49(Predicted)
form Crystalline Powder
color White to off-white
Water Solubility 622mg/L at 25℃
InChI InChI=1S/C6H4ClF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)
InChIKey WXNPZQIRDCDLJD-UHFFFAOYSA-N
SMILES C1(N)=NC=C(C(F)(F)F)C=C1Cl
LogP 2.59 at 20℃
CAS DataBase Reference 79456-26-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H412
Precautionary statements  P273-P301+P312+P330
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-52/53-36/37/38-20/21/22
Safety Statements  61-36/37/39-26-22
WGK Germany  2
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
REACH Registrations Active
NFPA 704
1
2 0

3-Chloro-5-(trifluoromethyl)pyridin-2-amine price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 366080 2-Amino-3-chloro-5-(trifluoromethyl)pyridine 97% 79456-26-1 25g $44.9 2023-06-20 Buy
TCI Chemical A1157 2-Amino-3-chloro-5-trifluoromethylpyridine >98.0%(GC) 79456-26-1 5g $38 2026-04-30 Buy
TCI Chemical A1157 2-Amino-3-chloro-5-trifluoromethylpyridine >98.0%(GC) 79456-26-1 25g $112 2026-04-30 Buy
SynQuest Laboratories 3H30-7-35 2-Amino-3-chloro-5-(trifluoromethyl)pyridine 97% 79456-26-1 1kg $295 2026-05-22 Buy
Synthonix A39238 2-Amino-3-chloro-5-(trifluoromethyl)pyridine 98% 79456-26-1 1g $15 2026-05-06 Buy
Product number Packaging Price Buy
366080 25g $44.9 Buy
A1157 5g $38 Buy
A1157 25g $112 Buy
3H30-7-35 1kg $295 Buy
A39238 1g $15 Buy

3-Chloro-5-(trifluoromethyl)pyridin-2-amine Chemical Properties,Uses,Production

Chemical Properties

Light yellow Cryst

Uses

2-Amino-3-chloro-5-trifluoromethylpyridine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.

Definition

ChEBI: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine is an aminopyridine.

Synthesis

2,3-Dichloro-5-(trifluoromethyl)pyridine

69045-84-7

3-Chloro-5-(trifluoromethyl)pyridin-2-amine

79456-26-1

Example 1: General procedure for the synthesis of 2-amino-3-chloro-5-trifluoromethylpyridine from 2,3-dichloro-5-trifluoromethylpyridine 1. Ammonolysis reaction: 2,3-dichloro-5-trifluoromethylpyridine (26.75 g, 0.125 mol) and water (25 ml) were added to an autoclave. After sealing, liquid ammonia (45 g, 2.85 mol) was added through a pressure bottle. The reaction mixture was heated to 80 °C and maintained for 9 h at 18-22 bar pressure. After cooling to room temperature, the intermediate 2-amino-3-chloro-5-trifluoromethylpyridine was obtained by filtration, washed with water and dried (22 g, 90% yield). 2. Condensation reaction: the above intermediate was dissolved in acetonitrile (230 ml), cooled to 5 ℃ and added solid KOH (12 g, 0.22 mol). A solution of 2,4-dichloro-3,5-dinitro-5-trifluoromethylbenzene (25 g, 0.08 mol) in acetonitrile (230 ml) was added slowly over 15 min under continuous cooling conditions. The reaction was gradually warmed up to 25°C for 4 hours and subsequently warmed up to 40°C for 2 hours. 3. Post-treatment: The reaction mixture was poured into water (1500 ml) and the pH was adjusted to about 4 with a 4N aqueous hydrochloric acid solution, followed by extraction with isopropyl acetate (2 x 750 ml). The organic phases were combined and concentrated to dryness to give the crude fludioxamine (43 g, 70% yield, 60% purity). The target product can be further purified by recrystallization.

References

[1] Patent: WO2014/198278, 2014, A1. Location in patent: Page/Page column 9; 17
[2] Heterocycles, 1984, vol. 22, # 1, p. 117 - 124
[3] Patent: US4349681, 1982, A

3-Chloro-5-(trifluoromethyl)pyridin-2-amine Preparation Products And Raw materials

Raw materials

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 2,3-Dichloro-5-(trifluoromethyl)pyridine Ammonia

Preparation Products

Fluazinam IMidazo[1,2-a]pyridine, 8-chloro-6-(trifluoroMethyl)-

3-Chloro-5-(trifluoromethyl)pyridin-2-amine Suppliers

Global( 336)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Jihui Chemical Co., Ltd.
+8615053042019 sales@jihuichem.com China 34 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3589 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 615 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Supplier Advantage
Shandong Jihui Chemical Co., Ltd.
58
Shaanxi Dideu Medichem Co. Ltd 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Changzhou Ansciep Chemical Co., Ltd. 		58

View Lastest Price from 3-Chloro-5-(trifluoromethyl)pyridin-2-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-3-chloro-5-(trifluoromethyl)pyridine pictures 2026-02-28 2-Amino-3-chloro-5-(trifluoromethyl)pyridine
79456-26-1
 US $0.00-0.00 / KG 25KG Purity: 99% 1000tons Shandong Jihui Chemical Co., Ltd.
Pal-GHK pictures 2025-12-12 Pal-GHK
79456-26-1
 US $1.00-100.00 / KG 1KG 95% 300KG Shaanxi Dideu Medichem Co. Ltd
3-Chloro-5-(trifluoromethyl)pyridin-2-amine pictures 2025-11-18 3-Chloro-5-(trifluoromethyl)pyridin-2-amine
79456-26-1
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited
  • Pal-GHK pictures
  • Pal-GHK
    79456-26-1
  • US $1.00-100.00 / KG
  • 95%
  • Shaanxi Dideu Medichem Co. Ltd

3-Chloro-5-(trifluoromethyl)pyridin-2-amine Spectrum

3-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)MS3-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)1HNMR3-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)13CNMR3-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)IR13-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)IR23-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)Raman

79456-26-1(3-Chloro-5-(trifluoromethyl)pyridin-2-amine)Related Search:

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Difluorochloromethane 3-AMINO-2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE, 97% MIN.,3-AMINO-2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE,2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDIN-3-AMINE Trifluoromethyl

1of4

TIMTEC-BB SBB003584 LABOTEST-BB LT00012608 2,3,5-actf 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINAMINE 3-Chloro-5-(trifluoromethyl)-2-pyridylamine 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-AMINE 2-Amino-3-Chloro-5-Trifluorome 2-Amino-3-chloro-5-(trifluoromethyl)pyridine 97% 2-Amino-3-chloro-5-(trifluoromethyl)pyridine97% 2-AMINO-3-CHLORO-5-TRIFLUOROMETHYLPYRIDI ACTP 2-Amino-3-chloro-5-trifluoropyridine 2-Amino-3-Chloro-5-Trifluromethyl Pyridine 2-Amino-3-chloro-5-trifluoromethylpyridine ,98% 3-Chloro-5-(trifluoromethyl)pyridin-2-amine, Tech. 3-Chloro-5-(trifluor 3-Chloro-5-trifluoroMethyl-pyridin-2-ylaMine 2-PyridinaMine, 3-chloro-5-(trifluoroMethyl)- 3-chloro-5-(trifluoromethyl)-4-pyridinamine 5-ACTF 2-Amino-3-chloro-5-(trifloromethyl)pyridine 3-Chloro-5-(trifluoromethyl)pyridin-2-amine, 6-Amino-5-chloro-alpha,alpha,alpha-trifluoro-3-picoline 2- aMino-3-chloro -5-three fluorineMethyl pyridine 2-Amino-3-chloro-5-trifluoromethylpyridine > 2-Amino-3-chloro-5-(trifluoromethyl) 3-Chloro-5-(trifluoromethyl)pyridin-2-amine ISO 9001：2015 REACH 3-Chloro-5-(trifluoromethyl)pyridin-2-amine, ACP 2-AMINO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE Compound Fr12847 79456-26-1 72600-65 71456-26-1 C6H4CIF3N2 C6H4ClF3N2 C6H4N2ClF3 Building Blocks Halopyridines Chloropyridines AMINO Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Fluorine series amine| alkyl chloride C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Chloropyridines Halopyridines Pyridines, Pyrimidines, Purines and Pteredines Pyridine series Amines Pyridines Pyridine