5-Hydroxy-2-methoxypyridine
- CAS No.
- 51834-97-0
- Chemical Name:
- 5-Hydroxy-2-methoxypyridine
- Synonyms
- 6-methoxypyridin-3-ol;Aficamten Impurity 9;6-Methoxy-3-pyridinol;Pyronoprene Impurity 48;3-Pyridinol, 6-methoxy-;6-METHOXY-HYDROXY-PYRIDINE;5-hydroxy-2-methoxypridine;5-HYDROXY-2-METHOXYPYRIDIN;3-Pyridinol,6-methoxy-(9CI);5-Hydroxy-2-methoxypyridine
- CBNumber:
- CB7281013
- Molecular Formula:
- C6H7NO2
- Molecular Weight:
- 125.13
- MDL Number:
- MFCD06858737
- MOL File:
- 51834-97-0.mol
- MSDS File:
- SDS
| Melting point | 81 °C |
|---|---|
| Boiling point | 330.1±22.0 °C(Predicted) |
| Density | 1.190±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | crystalline powder |
| pka | 9.69±0.10(Predicted) |
| color | Lemony beige |
| InChI | InChI=1S/C6H7NO2/c1-9-6-3-2-5(8)4-7-6/h2-4,8H,1H3 |
| InChIKey | LKBKDKVMHWPZDB-UHFFFAOYSA-N |
| SMILES | C1=NC(OC)=CC=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
5-Hydroxy-2-methoxypyridine price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR3808 | 5-Hydroxy-2-methoxypyridine 98% | 51834-97-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR3808 | 5-Hydroxy-2-methoxypyridine 98% | 51834-97-0 | 1g | $35 | 2026-06-04 | Buy |
| Activate Scientific | AS31307 | 5-Hydroxy-2-methoxylpyridine 98% | 51834-97-0 | 5g | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR3808 | 5-Hydroxy-2-methoxypyridine 98% | 51834-97-0 | 5g | $85 | 2026-06-04 | Buy |
| Activate Scientific | AS31307 | 5-Hydroxy-2-methoxylpyridine 98% | 51834-97-0 | 25g | $89 | 2026-06-04 | Buy |
5-Hydroxy-2-methoxypyridine Chemical Properties, Uses, Production
Uses
5-Hydroxy-2-methoxypyridine, is a heterocyclic building block used in various chemical synthesis.
Synthesis
13472-85-0
51834-97-0
Step 2. Synthesis of 5-hydroxy-2-methoxypyridine: To a stirred solution of 5-bromo-2-methoxypyridine (8.9 g, 47.9 mmol) in tetrahydrofuran (THF, 175 mL) was added slowly and dropwise to a solution of n-butyllithium (2.5 M hexane solution, 28.7 mL, 71.8 mmol) at -78 °C. The reaction was continued for 45 min with stirring. The reaction mixture was stirred continuously at -78 °C for 45 min. Subsequently, trimethyl borate (7.06 mL, 62.2 mmol) was added via syringe and the mixture continued to be stirred at the same temperature for 2 hours. The reaction mixture was warmed up to 0 °C and treated by adding a mixture of 3N NaOH solution (25 mL, 71.77 mmol) and 30% hydrogen peroxide solution (~50 mL). The reaction mixture gradually turned yellow and slightly turbid and was then warmed to room temperature, held for 30 minutes and then heated to reflux temperature and maintained for 1 hour. After completion of the reaction, the mixture was cooled to room temperature. The aqueous layer was neutralized with 1N HCl solution and subsequently extracted with ether (Et2O, 2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a yellow viscous oily product (3.5 g, 60% yield).
References
[1] Medicinal Chemistry Research, 2013, vol. 22, # 4, p. 1825 - 1836
[2] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71
[3] Patent: EP1449834, 2004, A2. Location in patent: Page 27
[4] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 33
[5] Patent: US2003/207914, 2003, A1. Location in patent: Page/Page column 12
5-Hydroxy-2-methoxypyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Lancent Medical Devices Co., Ltd. | 18111675298 | stochem@aliyun.com | China | 215 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 5-Hydroxy-2-methoxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 6-Methoxy-3-pyridinol
51834-97-0
|
$1.10-9.90 | 1KG | 99%min | 100KG | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-20 | 5-HYDROXY-2-METHOXYPYRIDINE
51834-97-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-08-13 | 5-HYDROXY-2-METHOXYPYRIDINE
51834-97-0
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. |
-
- 6-Methoxy-3-pyridinol
51834-97-0
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 5-HYDROXY-2-METHOXYPYRIDINE
51834-97-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-HYDROXY-2-METHOXYPYRIDINE
51834-97-0
- $0.00
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
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