3-Bromo-5-methylpyridine
- CAS No.
- 3430-16-8
- Chemical Name:
- 3-Bromo-5-methylpyridine
- Synonyms
- 3-brmo-5-me;3-Bromo-5-methyL;5-BROMO-3-PICOLINE;3-BROMO-5-METHYLPY...;3-brmo-5-methylpyridine;3-methy-5-bromopyridine;3-BROMO-5-METHYLPYRIDINE;3-Methyl-5-Bromopyridine;Pyridine, 3-bromo-5-methyl-;3-Bromo-5-methylpyridine >
- CBNumber:
- CB7416792
- Molecular Formula:
- C6H6BrN
- Molecular Weight:
- 172.02
- MDL Number:
- MFCD01646141
- MOL File:
- 3430-16-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 16.5-16.7 °C |
|---|---|
| Boiling point | 110°C/25mmHg(lit.) |
| Density | 1.4869 g/mL at 25 °C |
| refractive index | 1.5618 |
| Flash point | 91 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to lump to clear liquid |
| pka | 3.16±0.20(Predicted) |
| color | White or Colorless to Almost white or Almost colorless |
| InChI | 1S/C6H6BrN/c1-5-2-6(7)4-8-3-5/h2-4H,1H3 |
| InChIKey | ADCLTLQMVAEBLB-UHFFFAOYSA-N |
| SMILES | Cc1cncc(Br)c1 |
| CAS DataBase Reference | 3430-16-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-22 | |||||||||
| Safety Statements | 26-36/37/39-39 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
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| NFPA 704 |
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3-Bromo-5-methylpyridine price More Price(95)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 681245 | 3-Bromo-5-methylpyridine 97% | 3430-16-8 | 250mg | $128 | 2023-06-20 | Buy |
| TCI Chemical | B3724 | 3-Bromo-5-methylpyridine >98.0%(GC)(T) | 3430-16-8 | 1g | $36 | 2026-04-30 | Buy |
| TCI Chemical | B3724 | 3-Bromo-5-methylpyridine >98.0%(GC)(T) | 3430-16-8 | 5g | $141 | 2026-04-30 | Buy |
| Usbiological | 262113 | 3-Bromo-5-methylpyridine Asreported | 3430-16-8 | 10g | $412 | 2026-06-03 | Buy |
| Usbiological | 262113 | 3-Bromo-5-methylpyridine Asreported | 3430-16-8 | 25g | $654 | 2026-06-03 | Buy |
3-Bromo-5-methylpyridine Chemical Properties,Uses,Production
Chemical Properties
Light yellow liquid
Uses
5-Bromo-3-picoline is an intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity
Synthesis
625-92-3
823-96-1
3430-16-8
The general procedure for the synthesis of 3-bromo-5-methylpyridine from 3,5-dibromopyridine and trimethylcyclotriboroxane was as follows: under nitrogen protection, cesium carbonate (1.38 g, 4.22 mmol), trimethylcyclotriboroxane (0.2 mL, 1.47 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.488 g, 0.42 mmol ). Subsequently, a solution of 3,5-dibromopyridine (1.0 g, 4.22 mmol) dissolved in a 9:1 solvent mixture of dioxane and water (10 mL) was added. The reaction mixture was stirred at 110 °C for 16 hours. Upon completion of the reaction, trimethylcyclotriboroxane (0.2 mL, 1.47 mmol) was added again and the reaction temperature was lowered to 100 °C and the reaction continued to be stirred for 16 hours. At the end of the reaction, the reaction mixture was cooled to room temperature, filtered through diatomaceous earth and the filter cake was washed with ethyl acetate. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography with the eluent being a 80:20 solvent mixture of hexane and ethyl acetate, resulting in 3-bromo-5-methylpyridine as a colorless oil (0.654 g, 90% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 2.34 (s, 3H), 7.66 (s, 1H), 8.36 (s, 1H), 8.49 (s, 1H).GC-MS (EI) analysis showed: m/z = 171.0, 173.0 [M].
References
[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 25
3-Bromo-5-methylpyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 3-Bromo-5-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Bromo-5-methylpyridine
3430-16-8
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 3-Bromo-5-methylpyridine
3430-16-8
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 3-Bromo-5-methylpyridine
3430-16-8
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-Bromo-5-methylpyridine
3430-16-8
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 3-Bromo-5-methylpyridine
3430-16-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Bromo-5-methylpyridine
3430-16-8
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
