(S)-(+)-2-Methylpiperazine
- CAS No.
- 74879-18-8
- Chemical Name:
- (S)-(+)-2-Methylpiperazine
- Synonyms
- (S)-2-METHYLPIPERAZINE;S-MP;CADR-011;L-(+)-2-Meth;2-(S)-METHYLPIPERAZINE;(2S)-2-Methylpiperazine;L-(+)-2-Methylpiperazine;S-(+)-2-methylpyperazine;(S)-(+)-2-METHYLPIPERZINE;(S)-(+)-2-METHYLPIPERAZINE
- CBNumber:
- CB3781696
- Molecular Formula:
- C5H12N2
- Molecular Weight:
- 100.16
- MDL Number:
- MFCD00171452
- MOL File:
- 74879-18-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 91-93 °C(lit.) |
|---|---|
| Boiling point | 155-156 °C |
| alpha | 13.5 º (c=1, toluene) |
| Density | 0.9305 (estimate) |
| refractive index | 1.4378 (estimate) |
| Flash point | 149 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Crystalline Powder, Crystals and/or Chunks |
| pka | 9.31±0.40(Predicted) |
| color | White to yellow |
| optical activity | [α]20/D +6.8°, c = 1 in ethanol |
| Water Solubility | soluble |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 3647995 |
| InChI | 1S/C5H12N2/c1-5-4-6-2-3-7-5/h5-7H,2-4H2,1H3/t5-/m0/s1 |
| InChIKey | JOMNTHCQHJPVAZ-YFKPBYRVSA-N |
| SMILES | C[C@H]1CNCCN1 |
| CAS DataBase Reference | 74879-18-8(CAS DataBase Reference) |
| FDA UNII | C5VI3S1YC0 |
| UNSPSC Code | 12352005 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | F,Xi,C | |||||||||
| Risk Statements | 11-36/37/38-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45-36 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TM1225020 | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Sol. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
(S)-(+)-2-Methylpiperazine price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 397172 | (S)-(+)-2-Methylpiperazine 99% | 74879-18-8 | 1g | $25 | 2023-06-20 | Buy |
| Sigma-Aldrich | 397172 | (S)-(+)-2-Methylpiperazine 99% | 74879-18-8 | 5g | $91.5 | 2023-06-20 | Buy |
| TCI Chemical | M1424 | (S)-(+)-2-Methylpiperazine >97.0%(T) | 74879-18-8 | 1g | $67 | 2026-04-30 | Buy |
| TCI Chemical | M1424 | (S)-(+)-2-Methylpiperazine >97.0%(T) | 74879-18-8 | 5g | $139 | 2026-04-30 | Buy |
| Usbiological | 283439 | S-(+)-2-Methylpiperazine Asreported | 74879-18-8 | 10g | $352 | 2026-06-03 | Buy |
(S)-(+)-2-Methylpiperazine Chemical Properties, Uses, Production
Chemical Properties
white to yellow crystalline powder or chunks
Uses
Valuable synthon for quinoline antibacterials.
Synthesis
109-07-9
75336-86-6
74879-18-8
General procedure for the synthesis of (R)-(-)-2-methylpiperazine and (S)-2-methylpiperazine from 2-methylpiperazine: 1. In a 2L four-necked flask equipped with a thermometer, a vacuum stirrer and a cooling tube, 270 g (1.8 mol) of L-tartaric acid, 108 g (1.8 mol) of acetic acid and 270 g of water were added and stirred until completely dissolved. 2. add (±)-2-methylpiperazine 300 g (3.0 mol) and water 300 g. Heat to 85 °C or higher until completely dissolved. 3. cool to 68-74°C, add diastereomerically precipitated crystals of (R)-2-methylpiperazine and L-tartaric acid and age for 1 hour. 4. cooled to 12-18 °C over 5 h and filtered to obtain 440 g of wet biomass (diastereomeric salt) with a liquid content of 22.7 wt% and an optical purity of 92.3% ee. 5. 644 g of water and 440 g of the resulting crystals ((R)-2-methylpiperazine pure content = 132 g) were added to a 2L four-neck flask, followed by 162 g (2.2 mol) of calcium hydroxide, heated to 80 °C, and aged for 5 hours. 6. Cooled to 25 °C and filtered to give 586 g of crystals (mainly calcium L-tartrate) and 660 g of filtrate (containing 130 g of (R)-2-methylpiperazine). 7. The filtrate was concentrated under reduced pressure to a (R)-2-methylpiperazine concentration of 30%, 356 g of toluene was added, and the water was removed by azeotropic boiling by heating to 84-87 °C. 8. 212 g of toluene was distilled under reduced pressure, cooled to 47 °C, 0.01 g of (R)-2-methylpiperazine crystal seed was added and aged for 1 hour. 9. cooled to 5 °C, aged for 2 h, filtered and dried under vacuum to give 45 g of (R)-2-methylpiperazine crystals (chemical purity 100%, optical purity 99.5% ee). 10. For the synthesis of (S)-2-methylpiperazine, a similar procedure was used but with (S)-2-methylpiperazine as starting material, resulting in 66.8 g of (S)-2-methylpiperazine crystals (chemical purity 99.9%, optical purity 80.0%ee).
References
[1] Patent: JP2016/37495, 2016, A. Location in patent: Paragraph 0046-0052
(S)-(+)-2-Methylpiperazine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Changzhou HCK Biotech Co., Ltd. | 18796480679 15295163861 | 3844328290@qq.com | China | 602 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from (S)-(+)-2-Methylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-09 | (S)-(+)-2-Methylpiperazine
74879-18-8
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co | |
 |
2019-07-06 | (S)-(+)-2-Methylpiperazine
74879-18-8
|
$1.00 | 1kg | As customer's need | Career Henan Chemical Co |
-
- (S)-(+)-2-Methylpiperazine
74879-18-8
- $8.80
- 97%-99%
- Career Henan Chemical Co
-
- (S)-(+)-2-Methylpiperazine
74879-18-8
- $1.00
- As customer's need
- Career Henan Chemical Co
