E3 Ligase Ligand-Linker Conjugates 21

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E3 Ligase Ligand-Linker Conjugates 21 Basic information
Product Name:E3 Ligase Ligand-Linker Conjugates 21
Synonyms:E3 Ligand-Linker Conjugate 9;E3 Ligase Ligand-Linker Conjugates 21;E3 Ligase Ligand-Linker Conjugates 14 free base;Thalidomide-O-amido-PEG3-C2-NH2;Cereblon Ligand-Linker Conjugates 3;Acetamide, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;Thalidomide-O-amido-PEG3-NH2;N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS:1957236-20-2
MF:C23H30N4O9
MW:506.51
EINECS:
Product Categories:peg
Mol File:1957236-20-2.mol
E3 Ligase Ligand-Linker Conjugates 21 Structure
E3 Ligase Ligand-Linker Conjugates 21 Chemical Properties
Boiling point 788.8±60.0 °C(Predicted)
density 1.358±0.06 g/cm3(Predicted)
pka10.68±0.40(Predicted)
Safety Information
MSDS Information
E3 Ligase Ligand-Linker Conjugates 21 Usage And Synthesis
UsesThalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
IC 50Cereblon
References[1] Methods to induce targeted protein degradation through bifunctional molecules. WO 2017007612 A1
E3 Ligase Ligand-Linker Conjugates 21 Preparation Products And Raw materials
Tag:E3 Ligase Ligand-Linker Conjugates 21(1957236-20-2) Related Product Information
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 6 E3 Ligase Ligand-Linker Conjugates 22 E3 ligase Ligand-Linker Conjugates 11 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 ligase Ligand-Linker Conjugates 7 Free Base