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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903 |
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| Products Intro: |
Product Name:Thalidomide-O-amido-C8-NH2 hydrochloride
CAS:2415263-07-7
Purity:>=95%(HPLC) Package:100mg Remarks:S57261
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Thalidomide-O-amido-C8-NH2 hydrochloride manufacturers
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| | Thalidomide-O-amido-C8-NH2 hydrochloride Basic information |
| Product Name: | Thalidomide-O-amido-C8-NH2 hydrochloride | | Synonyms: | Thalidomide-O-amido-C8-NH2 hydrochloride;N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride;Thalidomide 4'-oxyacetamide-alkylC8-amine;Acetamide, N-(8-aminooctyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, hydrochloride (1:1) | | CAS: | 2415263-07-7 | | MF: | C23H31ClN4O6 | | MW: | 494.97 | | EINECS: | | | Product Categories: | | | Mol File: | 2415263-07-7.mol |  |
| | Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Properties |
| | Thalidomide-O-amido-C8-NH2 hydrochloride Usage And Synthesis |
| Uses | Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. | | Biological Activity | Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1]. | | IC 50 | Cereblon | | storage | Desiccate at RT | | References | [1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2. |
| | Thalidomide-O-amido-C8-NH2 hydrochloride Preparation Products And Raw materials |
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