t-Boc-N-Amido-PEG5-propargyl manufacturers
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| | t-Boc-N-Amido-PEG5-propargyl Basic information |
| Product Name: | t-Boc-N-Amido-PEG5-propargyl | | Synonyms: | t-Boc-N-Amido-PEG5-propargyl;Boc-NH-PEG5-propargyl;5,8,11,14,17-Pentaoxa-2-azaeicos-19-ynoic acid, 1,1-dimethylethyl ester;Propargyl-PEG5-NHBoc;BocNH-P5-Propargyl;Propargyl-PEG6-Boc Amine;Propargyl-PEG5-NHBoc/5,8,11,14,17-Pentaoxa-2-azaeicos-19-ynoic acid, 1,1-dimethylethyl ester;(3,6,9,12,15-pentaoxaoctadecyl-17-yne-1-yl) tert Butyl carbamate | | CAS: | 2062663-67-4 | | MF: | C18H33NO7 | | MW: | 375.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2062663-67-4.mol |  |
| | t-Boc-N-Amido-PEG5-propargyl Chemical Properties |
| | t-Boc-N-Amido-PEG5-propargyl Usage And Synthesis |
| Description | t-Boc-N-Amido-PEG5-propargyl comprises a propargyl group and Boc-protected amine. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine. | | Uses | Boc-NH-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-N-Amido-PEG5-propargyl Preparation Products And Raw materials |
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