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| | Boc-N-amido-PEG3-sulfonic acid Basic information |
| Product Name: | Boc-N-amido-PEG3-sulfonic acid | | Synonyms: | Boc-N-amido-PEG3-sulfonic acid;Boc-NH-PEG3-SO3H;Boc-NH-PEG3-sulfonic acid;5,8,11-Trioxa-2-azatridecanoic acid, 13-sulfo-, 1-(1,1-dimethylethyl) ester | | CAS: | 1817735-32-2 | | MF: | C13H27NO8S | | MW: | 357.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1817735-32-2.mol |  |
| | Boc-N-amido-PEG3-sulfonic acid Chemical Properties |
| density | 1.219±0.06 g/cm3(Predicted) | | pka | 1.34±0.50(Predicted) |
| | Boc-N-amido-PEG3-sulfonic acid Usage And Synthesis |
| Description | t-Boc-N-amido-PEG3-sulfonic acid is a PEG linker containing a t-Boc protected amine group and a sulfonic acid. The t-Boc protecting group can be removed under acidic conditions so that the amine can be further reacted. The sulfonic acid can undergo esterification, halogenation and displacement reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | | Uses | Boc-NH-PEG3-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Boc-N-amido-PEG3-sulfonic acid Preparation Products And Raw materials |
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