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| | 2-Bromopyridine-4-carboxylic acid Basic information |
| | 2-Bromopyridine-4-carboxylic acid Chemical Properties |
| Melting point | 229-231°C | | Boiling point | 447.2±30.0 °C(Predicted) | | density | 1.813±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Crystals or Crystalline Powder | | pka | 2.98±0.10(Predicted) | | color | White | | BRN | 471895 | | InChI | InChI=1S/C6H4BrNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10) | | InChIKey | YBTKGKVQEXAYEM-UHFFFAOYSA-N | | SMILES | C1(Br)=NC=CC(C(O)=O)=C1 | | CAS DataBase Reference | 66572-56-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-36/37 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
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ALFA
| English |
| | 2-Bromopyridine-4-carboxylic acid Usage And Synthesis |
| Chemical Properties | White to light brown powder | | Uses |
2-Bromoisonicotinic acid (CAS 66572-56-3) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
| | Application |
2-Bromopyridine-4-carboxylic acid is a kind of Pyridine carboxylic acid compounds, it can be used in medicine synthesis.
| | Health Hazard |
Accidental contact with 2-Bromopyridine-4-carboxylic acid causes skin irritation and serious eye irritation.
| | Synthesis | General procedure for the synthesis of 2-bromo-4-pyridinecarboxylic acid from 2-bromo-4-methylpyridine: To a stirred solution of 29.0 g (69 mmol) of 2-bromo-4-methylpyridine dissolved in 150 mL of concentrated sulfuric acid was added batchwise 67.9 g (231 mmol) of potassium dichromate. The reaction was cooled using an ice bath to maintain a constant temperature. After addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Subsequently, the reaction mixture was slowly poured into 2 L of ice water and stirred at room temperature for 1 hour. The resulting crystals were collected by filtration, washed with water until the eluent was colorless, and finally dried under vacuum to give 30.0 g (88% yield) of 2-bromo-4-pyridinecarboxylic acid. | | References | [1] Patent: US2011/111046, 2011, A1. Location in patent: Page/Page column 17; 18
[2] Patent: WO2011/58473, 2011, A1. Location in patent: Page/Page column 36; 37
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[4] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 9; 24
[5] Polyhedron, 2016, vol. 118, p. 159 - 170 |
| | 2-Bromopyridine-4-carboxylic acid Preparation Products And Raw materials |
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