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| O-Desmethyl Metoprolol Basic information |
| O-Desmethyl Metoprolol Chemical Properties |
Melting point | 70-720C | Boiling point | 424.6±40.0 °C(Predicted) | density | 1.085±0.06 g/cm3(Predicted) | storage temp. | -20°C Freezer | solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) | form | Solid | pka | 13.88±0.20(Predicted) | color | White to Off-White | InChI | InChI=1S/C14H23NO3/c1-11(2)15-9-13(17)10-18-14-5-3-12(4-6-14)7-8-16/h3-6,11,13,15-17H,7-10H2,1-2H3 | InChIKey | CUKXSBOAIJILRY-UHFFFAOYSA-N | SMILES | C1(CCO)=CC=C(OCC(O)CNC(C)C)C=C1 |
Toxicity | LD50 intravenous in dog: 150mg/kg |
| O-Desmethyl Metoprolol Usage And Synthesis |
Description | O-Desmethyl metoprolol is the major active metabolite of the β1-adrenergic receptor blocker metoprolol . It is formed by metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6 in vivo. | Chemical Properties | Off-White Solid | Uses | O-Desmethyl Metoprolol (Metoprolol EP Impurity H) is a metabolite of Metoprolol. |
| O-Desmethyl Metoprolol Preparation Products And Raw materials |
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