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D-Aspartic acid

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CAS:1783-96-6
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D-Aspartic acid manufacturers

  • D-Aspartic acid
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  • $10.00
  • 2026-07-11
  • CAS:1783-96-6
  • Min. Order: 1kg
  • Purity: 98.5%-101.0%
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  • D-Aspartic acid
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  • 2026-07-10
  • CAS:1783-96-6
  • Min. Order: 1kg
  • Purity: 99%min AJI
  • Supply Ability: 1000kg
D-Aspartic acid Basic information
Product Name:D-Aspartic acid
Synonyms:(R)-(-)-AMINOSUCCINIC ACID;(R)-AMINOSUCCINIC ACID;(R)-(-)-ASPARTIC ACID;1-Amino-1,2-carboxyethane;d-asparticaci;l-Asparagic acid;H-D-Asp;(R)-Aminosuccinic Acid D-Asparaginic Acid H-D-Asp-OH
CAS:1783-96-6
MF:C4H7NO4
MW:133.1
EINECS:217-234-6
Product Categories:Amino Acids & Derivatives;Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;amino;Aspartic acid [Asp, D];Amino Acids and Derivatives;for Resolution of Bases;alpha-Amino Acids;Amino Acids;Biochemistry;Optical Resolution;Synthetic Organic Chemistry;Amino Acids;Amino ACIDS SERIES;amino acid;aspartic acid;chemicals;organic acids;pharmaceutical intermediate;Glutamate receptor;chiral;Amino Acid Derivatives;bc0001
Mol File:1783-96-6.mol
D-Aspartic acid Structure
D-Aspartic acid Chemical Properties
Melting point >300 °C(lit.)
alpha -25.8 º (c=5, 5N HCl)
Boiling point 245.59°C (rough estimate)
density 1.66
refractive index -25 ° (C=8, 50% HCl)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Aqueous Acid (Sparingly)
pkapK1: 1.89(0);pK2: 3.65;pK3: 9.60 (25°C)
form Crystalline Powder
color White to off-white
Optical Rotation[α]20/D 24°, c = 2.3 in 6 M HCl
Water Solubility SOLUBLE
Merck 14,840
BRN 1723529
InChI1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
InChIKeyCKLJMWTZIZZHCS-UWTATZPHSA-N
SMILESN[C@H](CC(O)=O)C(O)=O
LogP-1.075 (est)
CAS DataBase Reference1783-96-6(CAS DataBase Reference)
NIST Chemistry ReferenceD-aspartic acid(1783-96-6)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
RTECS CI9097500
HS Code 29224995
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
D-Aminosuccinic acid English
SigmaAldrich English
ACROS English
ALFA English
D-Aspartic acid Usage And Synthesis
Chemical PropertiesWhite or almost white crystalline powder
UsesA non-essential amino acid found in food sources and dietary supplements. D-Aspartic acid's conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.
UsesD-Aspartic acid modulates melatonin synthesis in the pineal gland.
DefinitionChEBI: The D-enantiomer of aspartic acid.
ApplicationDietary inclusion of barley sprout, D-Aspartic acid, or their combination have a potential to improve various aspects of reproductive performance in aging roosters[2].
reaction suitabilityreaction type: solution phase peptide synthesis
Biological ActivityEndogenous NMDA receptor agonist with similar activity to the L-isomer (L-Aminosuccinic acid ). Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.
Synthesis
dimethyl L-aspartate

6384-18-5

D-Aspartic acid

1783-96-6

In a reaction vessel, 4.85 g (0.03 mol) of dimethyl (S)-2-aminosuccinate was added to 50 mL of 6 M potassium hydroxide solution and the hydrolysis reaction was carried out by heating and refluxing for 3 hrs. Upon completion of the reaction, the pH of the reaction solution was adjusted to 6.5 with 6 N hydrochloric acid.The reaction solution was purified by passing it through a regenerated cation exchange resin column and the effluent with pH=4 was collected. The collected effluent was concentrated under reduced pressure to one-fifth of the original volume and then precipitated by adding 95% methanol. The precipitate was collected by filtration and dried to give 3.3 g of D-aspartic acid in 82.5% yield.

storageRoom temperature
References [1] Patent: CN105503628,  2016,  A. Location in patent: Paragraph 0026
[2] Barbarestani, S. Y., Samadi, F., Pirsaraei, Z. A., & Zaghari, M. (2024). Barley sprouts and D-Aspartic acid supplementation improves fertility, hatchability, and semen quality in aging male broiler breeders by up-regulating StAR and P450SCC gene expressions. Poultry Science, 103 6, Article 103664. https://doi.org/10.1016/j.psj.2024.103664
Tag:D-Aspartic acid(1783-96-6) Related Product Information
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