2-Amino-4-bromobenzaldehyde

2-Amino-4-bromobenzaldehyde Suppliers list

Company Name:	Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. Gold
Tel:	025-66113011 13913916777
Email:	cfzhang@aikonchem.com

Company Name:	Xi'an duokai Trading Co., Ltd Gold
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Company Name:	BeiJing Hwrk Chemicals Limted
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2-Amino-4-bromobenzaldehyde manufacturers

2-Amino-4-bromobenzaldehyde Basic information

Product Name:	2-Amino-4-bromobenzaldehyde
Synonyms:	4-BroMo-2-aMinobenzaldehyde;Ambroxol Impurity 60;2-Amino-4-bromobenzaL;Benzaldehyde, 2-amino-4-bromo-;2-AMINO-4-BROMOBENZALDEHYDE ISO 9001：2015 REACH;2-Amino-4-bromobenzaldehyde
CAS:	59278-65-8
MF:	C7H6BrNO
MW:	200.03
EINECS:
Product Categories:	Aromatic Aldehydes & Derivatives (substituted)
Mol File:	59278-65-8.mol

2-Amino-4-bromobenzaldehyde Chemical Properties

Melting point	85 °C
Boiling point	317.1±32.0 °C(Predicted)
density	1.672±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka	-0.72±0.10(Predicted)
Appearance	Off-white to yellow Solid
InChI	InChI=1S/C7H6BrNO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H,9H2
InChIKey	ZZVUOSVSPAPBEJ-UHFFFAOYSA-N
SMILES	C(=O)C1=CC=C(Br)C=C1N

Safety Information

HS Code

2922390090

MSDS Information

2-Amino-4-bromobenzaldehyde Usage And Synthesis

Application	2-Amino-4-bromobenzaldehyde is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.
Synthesis	5551-12-2 59278-65-8 Step 3. Synthesis of 2-amino-4-bromobenzaldehyde: Iron powder was added to 0.2 M of 4-bromo-2-nitrobenzaldehyde in a mixed solvent system of acetic acid and ethanol (v/v 1:1) under argon protection. The reaction mixture was stirred at room temperature for 1.5 h. The completion of the reaction was confirmed by LCMS monitoring. The insoluble solids were removed by filtration and the filtrate was concentrated under vacuum. The residue was diluted with ethyl acetate, washed sequentially with saturated sodium bicarbonate solution and brine, and the organic phase was dried over anhydrous sodium sulfate and concentrated. The crude product was purified by Biotage system using hexane solution of 15% ethyl acetate as eluent to afford the target compound 2-amino-4-bromobenzaldehyde in 38% yield.ES/MS m/z 200/202 (MH+).
References	[1] Tetrahedron Letters, 2016, vol. 57, # 45, p. 5003 - 5008 [2] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 219 [3] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 333-334 [4] Chemische Berichte, 1909, vol. 42, p. 3697 [5] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 7, p. 2462 - 2467

2-Amino-4-bromobenzaldehyde Preparation Products And Raw materials

Raw materials	(E)-2-(4-bromo-2-nitrophenyl)-N,N-dimethylethenamine-->Methyl 2-amino-4-bromobenzoate-->4-Bromo-2-nitrobenzoic acid-->4-Bromo-2-nitrotoluene-->2-Amino-4-bromobenzyl alcohol-->4-Bromo-2-nitrobenzyl alcohol-->(2-Amino-5-bromophenyl)methanol-->4-Bromo-2-nitrobenzaldehyde-->Iron-->Acetic acid
Preparation Products	7-broMoquinolin-3-aMine

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