Thalidomide-linker 10 manufacturers
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| | Thalidomide-linker 10 Basic information |
| Product Name: | Thalidomide-linker 10 | | Synonyms: | Thalidomide-linker 10;-oxyacetamide-alkylC2-amine;Thalidomide-O-amido-C2-NH2;Thalidomide 4'-oxyacetamide-alkyl-C2-amine (hydrochloride);Thalidomide-O-amido-C2-NH2 hydrochloride;N-(2-aminoethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride;Thalidomide 4'-oxyacetamide-alkylC2-amine;Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | | CAS: | 2341841-02-7 | | MF: | C17H19ClN4O6 | | MW: | 410.81 | | EINECS: | | | Product Categories: | | | Mol File: | 2341841-02-7.mol |  |
| | Thalidomide-linker 10 Chemical Properties |
| storage temp. | 2-8°C, sealed storage, away from moisture and light | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | Thalidomide-linker 10 Usage And Synthesis |
| Uses | Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride can be used to design the PROTACs[1]. | | IC 50 | Cereblon | | storage | Store at -20°C | | References | [1] Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020;187:111952. DOI:10.1016/j.ejmech.2019.111952 |
| | Thalidomide-linker 10 Preparation Products And Raw materials |
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