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5-Bromo-2-fluoroaniline

5-Bromo-2-fluoroaniline Structure
5-Bromo-2-fluoroaniline structure
CAS No.
2924-09-6
Chemical Name:
5-Bromo-2-fluoroaniline
Synonyms
0/6/24;5-Bromo Aniline;5-BROMO-2-FLUOROANIL;5-Bromo-2-fuoroaniline;2-Fluoro-5-Bromoaniline;5-Bromo-2-fluoroaniline;2,4-di(propan-2-yl)phenol;5-Bromo-2-fluoroaniline ,98%;Benzenamine, 5-bromo-2-fluoro-;1-Amino-5-bromo-2-fluorobenzene
CBNumber:
CB0417457
Molecular Formula:
C6H5BrFN
Molecular Weight:
190.01
MDL Number:
MFCD03094181
MOL File:
2924-09-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:20
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5-Bromo-2-fluoroaniline Properties

Melting point 27℃
Boiling point 105 °C / 12mmHg
Density 1.694±0.06 g/cm3(Predicted)
refractive index 1.59
Flash point 27 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Solid
pka 2.13±0.10(Predicted)
color White or Colorless to Yellow to Orange
Water Solubility Slightly soluble in water.
InChI InChI=1S/C6H5BrFN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
InChIKey ADWKOCXRCRSMLQ-UHFFFAOYSA-N
SMILES C1(N)=CC(Br)=CC=C1F
CAS DataBase Reference 2924-09-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS07,GHS06
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H302-H312-H331-H335
Precautionary statements  P304+P340-P305+P351+P338-P405-P501a-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
Hazard Codes  T,Xi,Xn
Risk Statements  22-36-52-36/37/38-20/21/22
Safety Statements  26-60-36/37-9
RIDADR  2811
Hazard Note  Toxic
HazardClass  IRRITANT, TOXIC
HazardClass  6.1
HS Code  29214990
NFPA 704
0
2 0

5-Bromo-2-fluoroaniline price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B3043 5-Bromo-2-fluoroaniline >95.0%(GC) 2924-09-6 5g $23 2026-04-30 Buy
TCI Chemical B3043 5-Bromo-2-fluoroaniline >95.0%(GC) 2924-09-6 25g $78 2026-04-30 Buy
Usbiological 263826 5-Bromo-2-fluoroaniline Asreported 2924-09-6 5g $305 2026-06-03 Buy
Usbiological 263826 5-Bromo-2-fluoroaniline Asreported 2924-09-6 10g $389 2026-06-03 Buy
Usbiological 263826 5-Bromo-2-fluoroaniline Asreported 2924-09-6 25g $502 2026-06-03 Buy
Product number Packaging Price Buy
B3043 5g $23 Buy
B3043 25g $78 Buy
263826 5g $305 Buy
263826 10g $389 Buy
263826 25g $502 Buy

5-Bromo-2-fluoroaniline Chemical Properties, Uses, Production

Chemical Properties

Light yellow solid

Uses

5-Bromo-2-fluoroaniline is used as pharmaceutical intermediate.

Synthesis

4-Bromo-1-fluoro-2-nitrobenzene

364-73-8

5-BROMO-2-FLUOROANILINE

2924-09-6

General procedure for the synthesis of 5-bromo-2-fluoroaniline from 4-bromo-1-fluoro-2-nitrobenzene: 5-bromo-2-fluoro nitrobenzene (698 g) was dissolved in 95% ethanol (0.90 L), which was subsequently added to a mixed system of powdered iron (711 g) and saturated aqueous ammonium chloride (2.0 L). The reaction mixture was stirred continuously at 70°C for 24 hours (the reaction process was monitored by HPLC until complete). Upon completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to remove the solvent. The residue was subjected to liquid-liquid extraction with ethyl acetate (2 L) and water (2 L) to separate the organic and aqueous phases. The aqueous phase was further extracted once with ethyl acetate (1L). All organic phases were combined, washed with water (1 L), dried with anhydrous magnesium sulfate, filtered and the organic phase was concentrated under reduced pressure. Finally, 545.76 g of 5-bromo-2-fluoroaniline was obtained in 91% yield by high vacuum treatment for 5 h to completely remove the residual ethyl acetate.

References

[1] Patent: WO2006/48761, 2006, A2. Location in patent: Page/Page column 32
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 19, p. 4337 - 4341
[3] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 44
[4] Patent: WO2004/52847, 2004, A2. Location in patent: Page 171
[5] Patent: CN104530107, 2016, B. Location in patent: Paragraph 0022

5-Bromo-2-fluoroaniline synthesis

364-73-8
2924-09-6
Synthesis of 5-Bromo-2-fluoroaniline from 4-Bromo-1-fluoro-2-nitrobenzene

5-Bromo-2-fluoroaniline Preparation Products And Raw materials

Raw materials

4-Bromo-1-fluoro-2-nitrobenzene 4-Fluoro-3-nitroaniline Water 1-Fluoro-2-nitrobenzene Iron
Ethanol Ammonium chloride

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Preparation Products

2-Fluoroaniline 2,4-Dibromo-1-fluorobenzene 5-Bromo-2-fluorobenzenesulfonamide [1,1'-Biphenyl]-3-aMine, 4,4'-difluoro- 2-Bromo-5-fluorophenyl isothiocyanate
[1,1'-Biphenyl]-3-aMine, 4-fluoro-

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5-Bromo-2-fluoroaniline Suppliers

Global Suppliers ( 273)
Supplier Tel Email Country ProdList Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Nanjing Wanpu Pharmaceutical Technology Co.,Ltd 13814527050; 13814527050 3773605130@qq.com China 213 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Nanjing Wanpu Pharmaceutical Technology Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from 5-Bromo-2-fluoroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-BROMO-2-FLUOROANILINE pictures 2026-03-20 5-BROMO-2-FLUOROANILINE
2924-09-6
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
5-BROMO-2-FLUOROANILINE pictures 2021-08-12 5-BROMO-2-FLUOROANILINE
2924-09-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
5-BROMO-2-FLUOROANILINE pictures 2019-07-06 5-BROMO-2-FLUOROANILINE
2924-09-6
 $1.00 1kg 98% 100KG Career Henan Chemical Co

5-Bromo-2-fluoroaniline Spectrum

5-BROMO-2-FLUOROANILINE(2924-09-6)1HNMR

2924-09-6 (5-Bromo-2-fluoroaniline) Related Search:

3-Fluoro-4-broMoaniline 2-(Trifluoromethoxy)bromobenzene 2-BROMO-3-FLUOROANILINE 2,6-Dibromo-4-fluoroaniline Vandetanib
1-Bromo-3-fluoro-5-nitrobenzene 4-Fluorobenzoyl chloride 2-Fluoroaniline 2-Bromo-5-fluoroaniline 4-Bromo-2-fluoroaniline
2-Bromo-4-fluoroaniline 3-Bromo-4-fluoroaniline 3-Chloro-2,6-dibromo-4-fluoroaniline 2-(Difluoromethoxy)bromobenzene 2,4-Dibromo-6-fluoroaniline
2-Bromo-6-fluoroaniline 5-Bromo-2-fluoroaniline 3-Bromo-2-fluoroaniline

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2-Fluoro-5-Bromoaniline 5-Bromo-2-fluoro Aniline 2924-9-6 5-Bromo-2-fluoroaniline ,98% 5-BROMO-2-FLUOROANIL 1-Amino-5-bromo-2-fluorobenzene 5-Bromo-2-fuoroaniline 5-Bromo-2-fluoroaniline≥ 99% (GC) Benzenamine, 5-bromo-2-fluoro- 5-BROMO-2-FLUOROANILINE ISO 9001：2015 REACH TIANFU-CHEM CAS:2924-09-6 5-BROMO-2-FLUOROANILINE 2,4-di(propan-2-yl)phenol 5-Bromo Aniline 0/6/24 5-Bromo-2-fluoroaniline 2924-09-6 29424-09-6 374-25-9 2924-09-4 2924-9-6 2924-09-06 374259 C6H6BrCIFN Aniline series Benzenes Phenol&Thiophenol&Mercaptan Anilines, Aromatic Amines and Nitro Compounds