2-Chloro-5-fluoropyridine
- CAS No.
- 31301-51-6
- Chemical Name:
- 2-Chloro-5-fluoropyridine
- Synonyms
- 5-Fluoro-2-chloropyridine;2-CHLORO-5-FLUOROPYRIDINE;2-CHLORO-5-FLUOROPYPRIDINE;2-chloro-5-fluoridepyridine;2-Chloro-5-fluoropyridine98%;Pyridine, 2-chloro-5-fluoro-;2-Chloro-5-fluoropyridine >2-Chloro-5-fluoropyridine 98%;2-Chloro-5-fluoropyridine ,96%;2-Chloro-5-fluoropyridine ISO 9001：2015 REACH
- CBNumber:
- CB4390512
- Molecular Formula:
- C5H3ClFN
- Molecular Weight:
- 131.54
- MDL Number:
- MFCD03095332
- MOL File:
- 31301-51-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 19℃ |
|---|---|
| Boiling point | 74 °C / 38mmHg |
| Density | 1.297 g/mL at 25 °C |
| refractive index |
n |
| Flash point | 108 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to lump to clear liquid |
| pka | -2.20±0.10(Predicted) |
| color | White or Colorless to Light yellow |
| InChI | InChI=1S/C5H3ClFN/c6-5-2-1-4(7)3-8-5/h1-3H |
| InChIKey | QOGXQLSFJCIDNY-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(F)C=C1 |
| CAS DataBase Reference | 31301-51-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H315-H318-H335 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 10-22-37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-36/39-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Chloro-5-fluoropyridine price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 643556 | 2-Chloro-5-fluoropyridine 95% | 31301-51-6 | 5g | $71 | 2026-04-30 | Buy |
| Sigma-Aldrich | 643556 | 2-Chloro-5-fluoropyridine 95% | 31301-51-6 | 1g | $25 | 2023-06-20 | Buy |
| TCI Chemical | C2270 | 2-Chloro-5-fluoropyridine >98.0%(GC) | 31301-51-6 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | C2270 | 2-Chloro-5-fluoropyridine >98.0%(GC) | 31301-51-6 | 5g | $59 | 2026-04-30 | Buy |
| Usbiological | 159482 | 2-Chloro-5-fluoropyridine | 31301-51-6 | 2.5g | $425 | 2026-06-03 | Buy |
2-Chloro-5-fluoropyridine Chemical Properties, Uses, Production
Chemical Properties
Light yellow powder
Uses
2-Chloro-5-fluoropyridine, is the intermediate used for the synthesis of pharmaceuticals agents and biologically active compounds, such as pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Synthesis
5350-93-6
31301-51-6
The general procedure for the synthesis of 2-chloro-5-fluoropyridine from 2-chloro-5-aminopyridine is as follows: in a 25-mL three-necked flask equipped with a reflux condenser, thermocouple, and stirring system, 1 g (7.78 mmol) of 2-chloro-5-aminopyridine was dissolved in 14.3 g of o-dichlorobenzene, and added dropwise over a 5-min period of 5 min at room temperature to 1.64 g (11.5 mmol, 1.47 molar equivalents) of the boron trifluoride ethyl ether complex. Upon completion of the dropwise addition, the reaction solution was beige in color and accompanied by the formation of a precipitate. Subsequently, the reaction system was heated to 105 °C and maintained for 20 minutes before 1.05 g (9.2 mmol, 1.18 mole equivalents, 90% purity) of tert-butyl nitrite was added to 5.0 g of o-dichlorobenzene at a controlled titration rate of 25 ml/hr. The reaction was kept at 105 °C and continued for 25 min, after which the heating was stopped. The yield of 2-chloro-5-fluoropyridine was 36% as determined by 19F NMR.
References
[1] Patent: US2007/276168, 2007, A1. Location in patent: Page/Page column 9
2-Chloro-5-fluoropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ningbo Fuhe Chemical Co., Ltd. | 0574-1806900 18069001216 | nbfjj@126.com | China | 99 | 58 |
| Beijing DeLee Pharma Technology Co.,Ltd. | 17316103847 | sales@deleepharma.com | China | 234 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Latest Price from 2-Chloro-5-fluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2-Chloro-5-fluoropyridine
31301-51-6
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | 2-Chloro-5-fluoropyridine
31301-51-6
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-02 | 2-Chloro-5-fluoropyridine
31301-51-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Chloro-5-fluoropyridine
31301-51-6
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Chloro-5-fluoropyridine
31301-51-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Chloro-5-fluoropyridine
31301-51-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
