ChemicalBook >> CAS DataBase List >>2-Chloro-5-fluoropyridine

2-Chloro-5-fluoropyridine

2-Chloro-5-fluoropyridine structure

CAS No.: 31301-51-6

Chemical Name:: 2-Chloro-5-fluoropyridine

Synonyms: 5-Fluoro-2-chloropyridine;2-CHLORO-5-FLUOROPYRIDINE;2-CHLORO-5-FLUOROPYPRIDINE;2-chloro-5-fluoridepyridine;2-Chloro-5-fluoropyridine98%;Pyridine, 2-chloro-5-fluoro-;2-Chloro-5-fluoropyridine >2-Chloro-5-fluoropyridine 98%;2-Chloro-5-fluoropyridine ,96%;2-Chloro-5-fluoropyridine ISO 9001：2015 REACH

CBNumber:: CB4390512

Molecular Formula:: C5H3ClFN

Molecular Weight:: 131.54

MDL Number:: MFCD03095332

MOL File:: 31301-51-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:31

Product description	Number	Pack Size	Price
2-Chloro-5-fluoropyridine 95%	643556	5g	$71
2-Chloro-5-fluoropyridine 95%	643556	1g	$25
2-Chloro-5-fluoropyridine >98.0%(GC)	C2270	1g	$24
2-Chloro-5-fluoropyridine >98.0%(GC)	C2270	5g	$59
2-Chloro-5-fluoropyridine	C366765	2.5g	$140
More product size

Request For Quotation

2-Chloro-5-fluoropyridine Properties

Melting point	19℃
Boiling point	74 °C / 38mmHg
Density	1.297 g/mL at 25 °C
refractive index	n20/D 1.503
Flash point	108 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-2.20±0.10(Predicted)
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
InChI	InChI=1S/C5H3ClFN/c6-5-2-1-4(7)3-8-5/h1-3H
InChIKey	QOGXQLSFJCIDNY-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(F)C=C1
CAS DataBase Reference	31301-51-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07

Signal word

Danger

Hazard statements

H226-H302-H315-H318-H335

Precautionary statements

P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

10-22-37/38-41-36/37/38

Safety Statements

26-36/39-36

RIDADR

UN 1993 3/PG 3

WGK Germany

Hazard Note

Irritant

HazardClass

PackingGroup

III

HS Code

29339900

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

2-Chloro-5-fluoropyridine price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	643556	2-Chloro-5-fluoropyridine 95%	31301-51-6	5g	$71	2026-03-19	Buy
Sigma-Aldrich	643556	2-Chloro-5-fluoropyridine 95%	31301-51-6	1g	$25	2023-06-20	Buy
TCI Chemical	C2270	2-Chloro-5-fluoropyridine >98.0%(GC)	31301-51-6	1g	$24	2026-03-19	Buy
TCI Chemical	C2270	2-Chloro-5-fluoropyridine >98.0%(GC)	31301-51-6	5g	$59	2026-03-19	Buy
TRC	C366765	2-Chloro-5-fluoropyridine	31301-51-6	2.5g	$140	2021-12-16	Buy

Product number	Packaging	Price	Buy
643556	5g	$71	Buy
643556	1g	$25	Buy
C2270	1g	$24	Buy
C2270	5g	$59	Buy
C366765	2.5g	$140	Buy

2-Chloro-5-fluoropyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow powder

Uses

2-Chloro-5-fluoropyridine, is the intermediate used for the synthesis of pharmaceuticals agents and biologically active compounds, such as pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

Synthesis

5350-93-6

31301-51-6

The general procedure for the synthesis of 2-chloro-5-fluoropyridine from 2-chloro-5-aminopyridine is as follows: in a 25-mL three-necked flask equipped with a reflux condenser, thermocouple, and stirring system, 1 g (7.78 mmol) of 2-chloro-5-aminopyridine was dissolved in 14.3 g of o-dichlorobenzene, and added dropwise over a 5-min period of 5 min at room temperature to 1.64 g (11.5 mmol, 1.47 molar equivalents) of the boron trifluoride ethyl ether complex. Upon completion of the dropwise addition, the reaction solution was beige in color and accompanied by the formation of a precipitate. Subsequently, the reaction system was heated to 105 °C and maintained for 20 minutes before 1.05 g (9.2 mmol, 1.18 mole equivalents, 90% purity) of tert-butyl nitrite was added to 5.0 g of o-dichlorobenzene at a controlled titration rate of 25 ml/hr. The reaction was kept at 105 °C and continued for 25 min, after which the heating was stopped. The yield of 2-chloro-5-fluoropyridine was 36% as determined by 19F NMR.

References

[1] Patent: US2007/276168, 2007, A1. Location in patent: Page/Page column 9

2-Chloro-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Heptane 5-Amino-2-chloropyridine Isoamyl nitrite Fluoroboric acid tert-Butyl nitrite

Boron trifluoride diethyl etherate 1,2-Dichlorobenzene

1of2

Preparation Products

2-Cyano-5-fluoropyridine N-(2-chloro-5-luoropyridin-4-yl)nitraMide 6-chloro-3-fluoro-2-methoxyPyridine

2-Chloro-5-fluoropyridine Suppliers

Global( 388)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58

Supplier	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58
Changzhou Ditong Chemical Co.,Ltd	58
Shandong chuangyingchemical Co., Ltd.	58

View Lastest Price from 2-Chloro-5-fluoropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-25	2-Chloro-5-fluoropyridine 31301-51-6	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2025-04-04	2-Chloro-5-fluoropyridine 31301-51-6	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-02	2-Chloro-5-fluoropyridine 31301-51-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

2-Chloro-5-fluoropyridine
31301-51-6
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Chloro-5-fluoropyridine
31301-51-6
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Chloro-5-fluoropyridine
31301-51-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Chloro-5-fluoropyridine Spectrum

2-Chloro-5-fluoropyridine(31301-51-6)¹HNMR 2-Chloro-5-fluoropyridine(31301-51-6)FT-IR

31301-51-6(2-Chloro-5-fluoropyridine)Related Search:

2-Chloro-5-chloromethylpyridine 2-Chloro-3-cyanopyridine Flupirtine Epichlorohydrin Clopidol

Cyhalothrin Pentachloropyridine λ-Cyhalothrin 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine

3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 6-Chloro-2-methyl-3-nitropyridine 2-Chloro-5-hydroxypyridine 2-CHLORO-5-METHOXYPYRIDINE

2-Chloro-5-nitropyridine 2-Chloro-5-iodopyridine 5-Bromo-2-chlorobenzoic acid

1of4

2-CHLORO-5-FLUOROPYRIDINE 2-Chloro-5-fluoropyridine 98% 2-Chloro-5-fluoropyridine98% 2-Chloro-5-fluoropyridine ,96% 2-chloro-5-fluoridepyridine 5-Fluoro-2-chloropyridine 2-CHLORO-5-FLUOROPYPRIDINE Pyridine, 2-chloro-5-fluoro- 2-Chloro-5-fluoropyridine > 2-Chloro-5-fluoropyridine ISO 9001：2015 REACH 31301-51-6 1071-71-9 Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Pyridines derivates Chloropyridines Fluoropyridines Halopyridines Pyridine pyridine derivative Pyridines, Pyrimidines, Purines and Pteredines Boronic Acid C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Variety of halogenated heterocyclic series Fluorin-contained pyridine series Fluorine series Building Blocks C5 C5 to C6 Chemical Synthesis Fluorinated Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Heterocyclic Fluorinated Building Blocks Other Fluorinated Heterocycles bc0001