2-FLUORO-6-HYDROXYBENZALDEHYDE
- CAS No.
- 38226-10-7
- Chemical Name:
- 2-FLUORO-6-HYDROXYBENZALDEHYDE
- Synonyms
- 6-FLUOROSALICYLALDEHYDE;6-Fluorosalicylaldehyde>6-Fluorosalicylaldehyde,97%;4-Fluoro-4-nitroacetophneone;2-Fluor-6-Hydroxybenzaldehyde;2-FLUORO-6-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-6-hydroxy-;2-Fluoro-6-hydroxybenzaldehyde 98%;6-Fluorosalicylaldehyde, 3-Fluoro-2-formylphenol
- CBNumber:
- CB4306380
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MDL Number:
- MFCD01090996
- MOL File:
- 38226-10-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Fluorosalicylaldehyde >98.0%(GC)(T) | F0988 | 1g | $142 |
| 6-Fluorosalicylaldehyde >98.0%(GC)(T) | F0988 | 5g | $503 |
| 6-Fluorosalicylaldehyde | F595905 | 100mg | $120 |
| 6-Fluorosalicylaldehyde | 012410 | 100mg | $403 |
| 2-Fluoro-6-hydroxybenzaldehyde | W5897 | 25g | $295 |
| More product size | |||
| Melting point | 37-39°C |
|---|---|
| Boiling point | 201.3±20.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to lump |
| pka | 7.18±0.10(Predicted) |
| color | White to Yellow to Orange |
| Sensitive | Air Sensitive |
| BRN | 1935289 |
| InChI | InChI=1S/C7H5FO2/c8-6-2-1-3-7(10)5(6)4-9/h1-4,10H |
| InChIKey | FZIBGCDUHZBOLA-UHFFFAOYSA-N |
| SMILES | C(=O)C1=C(O)C=CC=C1F |
| CAS DataBase Reference | 38226-10-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39-27 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2912490090 | |||||||||
| NFPA 704 |
|
2-FLUORO-6-HYDROXYBENZALDEHYDE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0988 | 6-Fluorosalicylaldehyde >98.0%(GC)(T) | 38226-10-7 | 1g | $142 | 2025-07-31 | Buy |
| TCI Chemical | F0988 | 6-Fluorosalicylaldehyde >98.0%(GC)(T) | 38226-10-7 | 5g | $503 | 2025-07-31 | Buy |
| TRC | F595905 | 6-Fluorosalicylaldehyde | 38226-10-7 | 100mg | $120 | 2021-12-16 | Buy |
| Usbiological | 012410 | 6-Fluorosalicylaldehyde | 38226-10-7 | 100mg | $403 | 2021-12-16 | Buy |
| AK Scientific | W5897 | 2-Fluoro-6-hydroxybenzaldehyde | 38226-10-7 | 25g | $295 | 2021-12-16 | Buy |
2-FLUORO-6-HYDROXYBENZALDEHYDE Chemical Properties,Uses,Production
Uses
2-FLUORO-6-HYDROXYBENZALDEHYDE is used in the preparation of aromatic compounds as human PAI-1 inhibitors.
Synthesis
![Benzaldehyde, 2-fluoro-6-[(tetrahydro-2H-pyran-2-yl)oxy]-](/CAS/20210305/GIF/199388-02-8.gif)
199388-02-8
38226-10-7
Step 3: Synthesis of 2-fluoro-6-hydroxybenzaldehyde A solution of 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde (6.5 g, 29.0 mmol) and p-toluenesulfonic acid (TsOH, 2 g, 11.6 mmol) in dichloromethane (DCM, 30 mL) was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was diluted with dichloromethane (100 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 100:1 to 20:1 gradient elution) to afford 2-fluoro-6-hydroxybenzaldehyde (3.0 g, 74% yield) as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 11.49 (s, 1H), 10.29 (s, 1H), 7.46-7.52 (m, 1H), 6.79 (d, J = 8.8 Hz, 1H), 6.63-6.68 (m, 1H).
References
[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 19, p. 2925 - 2929
[2] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0096; 0378; 0382; 0383
2-FLUORO-6-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9983 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 2-FLUORO-6-HYDROXYBENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 2-FLUORO-6-HYDROXYBENZALDEHYDE
38226-10-7
|
US $1.00 / KG | 1KG | 95% | 500kg | Career Henan Chemical Co |
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- 2-FLUORO-6-HYDROXYBENZALDEHYDE
38226-10-7
- US $1.00 / KG
- 95%
- Career Henan Chemical Co
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