2-Fluoro-6-hydroxybenzaldehyde
- CAS No.
- 38226-10-7
- Chemical Name:
- 2-Fluoro-6-hydroxybenzaldehyde
- Synonyms
- 6-FLUOROSALICYLALDEHYDE;6-Fluorosalicylaldehyde>6-Fluorosalicylaldehyde,97%;4-Fluoro-4-nitroacetophneone;2-Fluor-6-Hydroxybenzaldehyde;2-Fluoro-6-hydroxybenzaldehyde;Benzaldehyde, 2-fluoro-6-hydroxy-;2-Fluoro-6-hydroxybenzaldehyde 98%;6-Fluorosalicylaldehyde, 3-Fluoro-2-formylphenol
- CBNumber:
- CB4306380
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MDL Number:
- MFCD01090996
- MOL File:
- 38226-10-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 37-39°C |
|---|---|
| Boiling point | 201.3±20.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 7.18±0.10(Predicted) |
| form | powder to lump |
| color | White to Yellow to Orange |
| Sensitive | Air Sensitive |
| BRN | 1935289 |
| InChI | InChI=1S/C7H5FO2/c8-6-2-1-3-7(10)5(6)4-9/h1-4,10H |
| InChIKey | FZIBGCDUHZBOLA-UHFFFAOYSA-N |
| SMILES | C(=O)C1=C(O)C=CC=C1F |
| CAS DataBase Reference | 38226-10-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39-27 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2912490090 | |||||||||
| NFPA 704 |
|
2-Fluoro-6-hydroxybenzaldehyde price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0988 | 6-Fluorosalicylaldehyde >98.0%(GC)(T) | 38226-10-7 | 1g | $122 | 2026-04-30 | Buy |
| TCI Chemical | F0988 | 6-Fluorosalicylaldehyde >98.0%(GC)(T) | 38226-10-7 | 5g | $431 | 2026-04-30 | Buy |
| Usbiological | 012410 | 6-Fluorosalicylaldehyde | 38226-10-7 | 100mg | $403 | 2026-06-03 | Buy |
| Biosynth | FF23491 | 6-Fluorosalicylaldehyde | 38226-10-7 | 1g | $150 | 2026-06-04 | Buy |
| Biosynth | FF23491 | 6-Fluorosalicylaldehyde | 38226-10-7 | 2g | $226.8 | 2026-06-04 | Buy |
2-Fluoro-6-hydroxybenzaldehyde Chemical Properties, Uses, Production
Uses
2-FLUORO-6-HYDROXYBENZALDEHYDE is used in the preparation of aromatic compounds as human PAI-1 inhibitors.
Synthesis
![Benzaldehyde, 2-fluoro-6-[(tetrahydro-2H-pyran-2-yl)oxy]-](/CAS/20210305/GIF/199388-02-8.gif)
199388-02-8
38226-10-7
Step 3: Synthesis of 2-fluoro-6-hydroxybenzaldehyde A solution of 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde (6.5 g, 29.0 mmol) and p-toluenesulfonic acid (TsOH, 2 g, 11.6 mmol) in dichloromethane (DCM, 30 mL) was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was diluted with dichloromethane (100 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 100:1 to 20:1 gradient elution) to afford 2-fluoro-6-hydroxybenzaldehyde (3.0 g, 74% yield) as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 11.49 (s, 1H), 10.29 (s, 1H), 7.46-7.52 (m, 1H), 6.79 (d, J = 8.8 Hz, 1H), 6.63-6.68 (m, 1H).
References
[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 19, p. 2925 - 2929
[2] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0096; 0378; 0382; 0383
2-Fluoro-6-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Bohan Chemical Co., Ltd | 15851960282 | 2770577045@qq.com | China | 30 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 2-Fluoro-6-hydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-FLUORO-6-HYDROXYBENZALDEHYDE
38226-10-7
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- 2-FLUORO-6-HYDROXYBENZALDEHYDE
38226-10-7
- $1.00
- 95%
- Career Henan Chemical Co
38226-10-7 (2-Fluoro-6-hydroxybenzaldehyde) Related Search:
1of4
