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N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL structure

CAS No.: 73365-02-3

Chemical Name:: N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

Synonyms: (R)-tert-butyl 2-forMylpyrrolidine-1-carboxylate;Boc-D-prolyne;BOC-D-PROLINAL;(R)-N-BOC-PROLINAL;N-T-BOC-D-PROLINAL;(R)-N-BOC-PROLINAL, 97+%;(R)-1-Boc-2-formylpyrrolidine;N-(TERT-BUTOXYCARBONYL)-D-PROLINAL;(R)-(+)-1-BOC-2-PYRROLIDINECARBALDEHYDE;S-(+)-N-(diphenylmethylene)glycinesultam

CBNumber:: CB8215406

Molecular Formula:: C10H17NO3

Molecular Weight:: 199.25

MDL Number:: MFCD01321389

MOL File:: 73365-02-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:50

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N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Properties

Boiling point	228 °C(lit.)
alpha	+83°(23℃, neat)
Density	1.059 g/mL at 25 °C(lit.)
refractive index	n20/D 1.461(lit.)
Flash point	>230 °F
storage temp.	-20°C
form	Liquid
pka	-3.03±0.40(Predicted)
Specific Gravity	1.059
color	Colorless to yellow
optical activity	[α]23/D +83°, neat
Sensitive	Air Sensitive
InChI	InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h7-8H,4-6H2,1-3H3/t8-/m1/s1
InChIKey	YDBPZCVWPFMBDH-MRVPVSSYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC[C@@H]1C=O
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29339980

NFPA 704

	1
2		0

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	483788	N-(tert-Butoxycarbonyl)-D-prolinal 97%	73365-02-3	1g	$49.75	2025-07-31	Buy
Sigma-Aldrich	483788	N-(tert-Butoxycarbonyl)-D-prolinal 97%	73365-02-3	5g	$395	2023-06-20	Buy
TCI Chemical	B5395	N-(tert-Butoxycarbonyl)-D-prolinal	73365-02-3	1G	$93	2025-07-31	Buy
Usbiological	265613	Boc-D-prolinal	73365-02-3	500mg	$382	2021-12-16	Buy
Matrix Scientific	074620	N-Boc-D-Prolinal 95+%	73365-02-3	10g	$395	2021-12-16	Buy

Product number	Packaging	Price	Buy
483788	1g	$49.75	Buy
483788	5g	$395	Buy
B5395	1G	$93	Buy
265613	500mg	$382	Buy
074620	10g	$395	Buy

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

59378-81-3

73365-02-3

1. tert-Butyl (2R)-2-formylpyrrolidine-1-carboxylate (15.9 g, 37.4 mmol) was added in batches to a stirring solution of tert-Butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (5.0 g, 24.9 mmol) in dichloromethane (75 mL) under nitrogen protection over a 5-minute dosing period. 2. The reaction mixture was stirred for 1 hr. to form a suspension.3. The suspension was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (100 mL).4. The filtrate was concentrated under pressure to give the crude product.5. The crude product was purified by neutral silica gel column chromatography to give BOC-D-prolinyl aldehyde (4.4 g, 89% yield) using 12% ethyl acetate/hexanes as eluent.

References

[1] Patent: WO2015/120390, 2015, A1. Location in patent: Page/Page column 97; 178
[2] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[3] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 94; 95
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 12, p. 3190 - 3198
[5] Tetrahedron Letters, 1990, vol. 31, # 28, p. 3957 - 3960

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Preparation Products And Raw materials

Raw materials

N-Boc-D-proline 1-Pyrrolidinecarboxylic acid, 2-[(ethylthio)carbonyl]-, 1,1-dimethylethyl ester, (2R)- (R)-1-Boc-pyrrolidin-2-yl-methanol Dichloromethane Dess-Martin periodinane

Preparation Products

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Fred Technology Co., Ltd	+86-25-84696168 +86-15380713688	Austin@fredbio.com	China	2428	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	12887	58
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Suzhou Ryan Pharmachem Technology Co.,Ltd.	+86-512-68780025 +8618962125825	sales@ryanchem.com	China	136	58

Supplier	Advantage
Nanjing Fred Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Chembon Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Fuxin Pharmaceutical	58
Suzhou Ryan Pharmachem Technology Co.,Ltd.	58

View Lastest Price from N-(TERT-BUTOXYCARBONYL)-D-PROLINAL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-26	N-Boc-D-Prolinal 73365-02-3	US $0.00-0.00 / kg	0.1kg	98%(GC);99%ee	500kg	Nanjing Fred Technology Co., Ltd
	2019-07-06	N-(TERT-BUTOXYCARBONYL)-D-PROLINAL 73365-02-3	US $1.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

N-Boc-D-Prolinal
73365-02-3
US $0.00-0.00 / kg
98%(GC);99%ee
Nanjing Fred Technology Co., Ltd

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL
73365-02-3
US $1.00 / KG
99%
Career Henan Chemical Co

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Spectrum

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL(73365-02-3)¹HNMR N-(TERT-BUTOXYCARBONYL)-D-PROLINAL(73365-02-3)IR

73365-02-3(N-(TERT-BUTOXYCARBONYL)-D-PROLINAL)Related Search:

N-(TERT-BUTOXYCARBONYL)-L-PROLINAL,(S)-N-Boc-pyrrolidine-2-carboxaldehyde, N-(tert-Butoxycarbonyl)-L-prolinal (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid BOC-D-PRO-OSU D-1-N-Boc-prolinamide N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-PRO-OME (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate BOC-D-PRO-D-PHE-OH (R)-2-(2-ETHOXYCARBONYL-ACETYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

BOC-D-PRO-GLY-OH BOC-D-PRO-PAM RESIN (R)-4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER BOC-CIS-3-HYDROXY-D-PROLINE BOC-D-PRO-PHE-OH

(2R,5S)-BOC-5-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID BOC-(S)-ALPHA-BENZYL-PROLINE AKOS 92832

1of4

(R)-2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-(+)-1-BOC-2-PYRROLIDINECARBALDEHYDE (R)-N-BOC-PROLINAL N-(TERT-BUTOXYCARBONYL)-D-PROLINAL N-T-BOC-D-PROLINAL BOC-D-PROLINAL (R)-2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-N-BOC-PROLINAL (R)-N-BOC-PROLINAL, 97+% S-(+)-N-(diphenylmethylene)glycinesultam 1-Pyrrolidinecarboxylicacid, 2-formyl-, 1,1-dimethylethyl ester, (2R)- (R)-tert-butyl 2-forMylpyrrolidine-1-carboxylate (R)-1-Boc-2-formylpyrrolidine tert-butyl (2R)-2-formylpyrrolidine-1-carboxylate N-(TERT-BUTOXYCARBONYL)-D-PROLINAL USP/EP/BP Boc-D-prolyne N-(tert-Butoxycarbonyl)-D-prolinal 73365-02-3 Amino Acid Derivatives Amino Aldehydes Specialty Synthesis Peptide Synthesis Amino Aldehydes Amino Acid Derivatives Peptide Synthesis