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N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL structure

CAS No.: 73365-02-3

Chemical Name:: N-(TERT-BUTOXYCARBONYL)-D-PROLINAL

Synonyms: (R)-tert-butyl 2-forMylpyrrolidine-1-carboxylate;Boc-D-prolyne;BOC-D-PROLINAL;(R)-N-BOC-PROLINAL;N-T-BOC-D-PROLINAL;(R)-N-BOC-PROLINAL, 97+%;(R)-1-Boc-2-formylpyrrolidine;N-(TERT-BUTOXYCARBONYL)-D-PROLINAL;(R)-(+)-1-BOC-2-PYRROLIDINECARBALDEHYDE;S-(+)-N-(diphenylmethylene)glycinesultam

CBNumber:: CB8215406

Molecular Formula:: C10H17NO3

Molecular Weight:: 199.25

MDL Number:: MFCD01321389

MOL File:: 73365-02-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:52:49

Request For Quotation

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Properties

Boiling point	228 °C(lit.)
alpha	+83°(23℃, neat)
Density	1.059 g/mL at 25 °C(lit.)
refractive index	n20/D 1.461(lit.)
Flash point	>230 °F
storage temp.	-20°C
form	Liquid
pka	-3.03±0.40(Predicted)
Specific Gravity	1.059
color	Colorless to yellow
optical activity	[α]23/D +83°, neat
Sensitive	Air Sensitive
Major Application	peptide synthesis
InChI	InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h7-8H,4-6H2,1-3H3/t8-/m1/s1
InChIKey	YDBPZCVWPFMBDH-MRVPVSSYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC[C@@H]1C=O
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29339980

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	483788	N-(tert-Butoxycarbonyl)-D-prolinal 97%	73365-02-3	1g	$105	2026-04-30	Buy
Sigma-Aldrich	483788	N-(tert-Butoxycarbonyl)-D-prolinal 97%	73365-02-3	5g	$395	2023-06-20	Buy
TCI Chemical	B5395	N-(tert-Butoxycarbonyl)-D-prolinal	73365-02-3	1G	$56	2026-04-30	Buy
Usbiological	265613	Boc-D-prolinal Asreported	73365-02-3	500mg	$382	2026-06-03	Buy
Usbiological	265613	Boc-D-prolinal Asreported	73365-02-3	1g	$615	2026-06-03	Buy

Product number	Packaging	Price	Buy
483788	1g	$105	Buy
483788	5g	$395	Buy
B5395	1G	$56	Buy
265613	500mg	$382	Buy
265613	1g	$615	Buy

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

59378-81-3

73365-02-3

1. tert-Butyl (2R)-2-formylpyrrolidine-1-carboxylate (15.9 g, 37.4 mmol) was added in batches to a stirring solution of tert-Butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (5.0 g, 24.9 mmol) in dichloromethane (75 mL) under nitrogen protection over a 5-minute dosing period. 2. The reaction mixture was stirred for 1 hr. to form a suspension.3. The suspension was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (100 mL).4. The filtrate was concentrated under pressure to give the crude product.5. The crude product was purified by neutral silica gel column chromatography to give BOC-D-prolinyl aldehyde (4.4 g, 89% yield) using 12% ethyl acetate/hexanes as eluent.

References

[1] Patent: WO2015/120390, 2015, A1. Location in patent: Page/Page column 97; 178
[2] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[3] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 94; 95
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 12, p. 3190 - 3198
[5] Tetrahedron Letters, 1990, vol. 31, # 28, p. 3957 - 3960

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Preparation Products And Raw materials

Raw materials

N-Boc-D-proline 1-Pyrrolidinecarboxylic acid, 2-[(ethylthio)carbonyl]-, 1,1-dimethylethyl ester, (2R)- (R)-1-Boc-pyrrolidin-2-yl-methanol Dichloromethane Dess-Martin periodinane

Preparation Products

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Suppliers

Global( 174)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Taizhou FRIEND Chemical Co., Ltd.	025-0523-86200082 15380713688	Austin@fredchem.cn	China	153	55
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
ITIC MEDCHEM(SUZHOU) CO.,LTD.	0512-68323967 18015559028	sales@iticmedchem.com	China	528	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Taizhou FRIEND Chemical Co., Ltd.	55
Shanghai Hobor Chemical Co., Ltd	60
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
ITIC MEDCHEM(SUZHOU) CO.,LTD.	61
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Lastest Price from N-(TERT-BUTOXYCARBONYL)-D-PROLINAL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Boc-D-prolinal 73365-02-3	$1.10-9.90	1KG	99%min	100KG	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2024-11-26	N-Boc-D-Prolinal 73365-02-3			98%(GC);99%ee	500kg	Nanjing Fred Technology Co., Ltd
2019-07-06	N-(TERT-BUTOXYCARBONYL)-D-PROLINAL 73365-02-3	$1.00	1KG	99%		Career Henan Chemical Co

Boc-D-prolinal
73365-02-3
$1.10-9.90
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

N-Boc-D-Prolinal
73365-02-3
98%(GC);99%ee
Nanjing Fred Technology Co., Ltd

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL
73365-02-3
$1.00
99%
Career Henan Chemical Co

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Spectrum

N-(TERT-BUTOXYCARBONYL)-D-PROLINAL(73365-02-3)¹HNMR N-(TERT-BUTOXYCARBONYL)-D-PROLINAL(73365-02-3)IR

73365-02-3(N-(TERT-BUTOXYCARBONYL)-D-PROLINAL)Related Search:

N-(TERT-BUTOXYCARBONYL)-L-PROLINAL,(S)-N-Boc-pyrrolidine-2-carboxaldehyde, N-(tert-Butoxycarbonyl)-L-prolinal Boc-D-Pro-OMe (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid N-(TERT-BUTOXYCARBONYL)-D-PROLINAL (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate D-1-N-Boc-prolinamide BOC-D-PRO-OSU (R)-4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER BOC-CIS-3-HYDROXY-D-PROLINE

BOC-D-PRO-PHE-OH (2R,5S)-BOC-5-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID BOC-(S)-ALPHA-BENZYL-PROLINE (R)-2-(2-ETHOXYCARBONYL-ACETYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Boc-D-Pro-pam resin

Boc-D-Pro-Gly-OH Boc-D-Pro-D-Phe-OH AKOS 92832

1of4

(R)-2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-(+)-1-BOC-2-PYRROLIDINECARBALDEHYDE (R)-N-BOC-PROLINAL N-(TERT-BUTOXYCARBONYL)-D-PROLINAL N-T-BOC-D-PROLINAL BOC-D-PROLINAL (R)-2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-N-BOC-PROLINAL (R)-N-BOC-PROLINAL, 97+% S-(+)-N-(diphenylmethylene)glycinesultam 1-Pyrrolidinecarboxylicacid, 2-formyl-, 1,1-dimethylethyl ester, (2R)- (R)-1-Boc-2-formylpyrrolidine tert-butyl (2R)-2-formylpyrrolidine-1-carboxylate N-(TERT-BUTOXYCARBONYL)-D-PROLINAL USP/EP/BP Boc-D-prolyne N-(tert-Butoxycarbonyl)-D-prolinal (R)-tert-butyl 2-forMylpyrrolidine-1-carboxylate 73365-02-3 Amino Acid Derivatives Amino Aldehydes Specialty Synthesis Peptide Synthesis Amino Aldehydes Amino Acid Derivatives Peptide Synthesis