2-Fluoro-3-trifluoromethylpyridine
- CAS No.
- 65753-52-8
- Chemical Name:
- 2-Fluoro-3-trifluoromethylpyridine
- Synonyms
- 2-FLUORO-3-(TRIFLUOROMETHOXY)PYRIDINE;2-FLUORO-TRIFLUOROMETHYLPYRIDINE;2-Floro-3-(trifluoroMethyl)pyridine;-Fluoro-3-(trifluoromethyl)pyridine;2-FLUORO-3-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-fluoro-3-(trifluoroMethyl)-;2-Fluoro-3-(trifluoromethyl)pyridine(FTF);alpha,alpha,alpha,2-Tetrafluoro-3-picoline;2-Fluoro-3-trifluoromethylpyridine Chemical Properties;2-Fluoro-3-trifluoromethylpyridine ISO 9001：2015 REACH
- CBNumber:
- CB9317299
- Molecular Formula:
- C6H3F4N
- Molecular Weight:
- 165.09
- MDL Number:
- MFCD04973416
- MOL File:
- 65753-52-8.mol
- MSDS File:
- SDS
| Boiling point | 134-137 °C |
|---|---|
| Density | 1.371±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -2.86±0.10(Predicted) |
| form | liquid |
| color | Clear, colourless |
| InChI | 1S/C6H3F4N/c7-5-4(6(8,9)10)2-1-3-11-5/h1-3H |
| InChIKey | UTAQOVYPSZIDTK-UHFFFAOYSA-N |
| SMILES | Fc1ncccc1C(F)(F)F |
| CAS DataBase Reference | 65753-52-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H227-H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| Hazard Codes | Xi,Xn,T |
| Risk Statements | 20/21/22-36/37/38-36-25 |
| Safety Statements | 26-36/37/39-36-45 |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Oral Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1B STOT RE 1 |
2-Fluoro-3-trifluoromethylpyridine price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 417677 | 2-Fluoro-3-(trifluoromethyl)pyridine | 65753-52-8 | 100mg | $312 | 2026-06-03 | Buy |
| Usbiological | 417677 | 2-Fluoro-3-(trifluoromethyl)pyridine | 65753-52-8 | 1g | $396 | 2026-06-03 | Buy |
| Apolloscientific | PC9924 | 2-Fluoro-3-(trifluoromethyl)pyridine 98% | 65753-52-8 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC9924 | 2-Fluoro-3-(trifluoromethyl)pyridine 98% | 65753-52-8 | 25g | $75 | 2026-06-04 | Buy |
| AK Scientific | J61624 | 2-Fluoro-3-trifluoromethylpyridine 95% | 65753-52-8 | 1g | $12 | 2026-06-04 | Buy |
2-Fluoro-3-trifluoromethylpyridine Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Uses
2-Fluoro-3-(trifluoromethyl)pyridine is a useful synthetic intermediate. It is used to prepare antihypertensive β-adrenergic blocking agents. It is also used to synthesize HCV NS5B thumb pocket 2 allosteric inhibitors.
Synthesis
65753-47-1
65753-52-8
General procedure for the synthesis of 2-chloro-3-trifluoromethylpyridine from 2-chloro-3-trifluoromethylpyridine: In a desiccator, anhydrous tetramethylammonium fluoride (NMe4F, 18.6 mg, 0.2 mmol, 2 eq.) and 2-chloro-3-trifluoromethylpyridine (0.1 mmol, 1 eq.) were accurately weighed in a 4 mL sample vial, in which a micro stirring bar was placed in advance. Subsequently, N,N-dimethylformamide (DMF, 0.5 mL) was added as solvent. The sample bottle was removed from the desiccator and the reaction was stirred at room temperature for 24 hours unless otherwise stated. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the internal standard (1,3,5-trifluorobenzene, 100 μL of 0.5 M toluene solution) was added. An appropriate amount of the reaction mixture was taken and analyzed by fluorine-19 nuclear magnetic resonance (59F NMR) spectroscopy and gas chromatography-mass spectrometry (GCMS).
References
[1] Chemistry Letters, 1993, # 3, p. 509 - 512
[2] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[3] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145
[4] Patent: WO2017/24167, 2017, A1. Location in patent: Page/Page column 29; 33
[5] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017; 0020; 0023
2-Fluoro-3-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| NOTA Chemical (Shanghai) Co.,Ltd | 021-50189163 | sales@notachem.com | China | 208 | 64 |
View Latest Price from 2-Fluoro-3-trifluoromethylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Fluoro-3-trifluoromethylpyridine
65753-52-8
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-10-16 | 2-Fluoro-3-trifluoromethylpyridine Chemical Properties
65753-52-8
|
$10.00 | 1KG | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2019-07-06 | 2-Fluoro-3-trifluoromethylpyridine
65753-52-8
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 2-Fluoro-3-trifluoromethylpyridine
65753-52-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Fluoro-3-trifluoromethylpyridine Chemical Properties
65753-52-8
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 2-Fluoro-3-trifluoromethylpyridine
65753-52-8
- $1.00
- 98%
- Career Henan Chemical Co
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