- Cbz-L-Ala-OL
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-
2026-08-31
- CAS:66674-16-6
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- CBZ-L-ALANINOL
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2025-04-04
- CAS:66674-16-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
- CBZ-L-ALANINOL
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- $15.00
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2021-08-12
- CAS:66674-16-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
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| | CBZ-L-ALANINOL Basic information |
| Product Name: | CBZ-L-ALANINOL | | Synonyms: | (S)-(2-HYDROXY-1-METHYLETHYL)CARBAMIC ACID BENZYL ESTER;(S)-(-)-2-(Z-AMINO)-1-PROPANOL;N-CARBOBENZOXY-L-ALANINOL;N-Z-L-ALANINOL;Z-ALA-OL;Z-ALANINOL;Z-L-ALANINOL;CBZ-L-ALANINOL | | CAS: | 66674-16-6 | | MF: | C11H15NO3 | | MW: | 209.24 | | EINECS: | 822-974-3 | | Product Categories: | | | Mol File: | 66674-16-6.mol |  |
| | CBZ-L-ALANINOL Chemical Properties |
| Melting point | 81-84 °C (lit.) | | Boiling point | 375.2±35.0 °C(Predicted) | | density | 1.149±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in ethanol. | | form | powder to crystal | | pka | 11.90±0.46(Predicted) | | color | White to Almost white | | Optical Rotation | [α]20/D 8.0, c = 2% in ethanol | | Major Application | peptide synthesis | | InChI | 1S/C11H15NO3/c1-9(7-13)12-11(14)15-8-10-5-3-2-4-6-10/h2-6,9,13H,7-8H2,1H3,(H,12,14)/t9-/m0/s1 | | InChIKey | AFPHMHSLDRPUSM-VIFPVBQESA-N | | SMILES | C[C@@H](CO)NC(=O)OCc1ccccc1 | | CAS DataBase Reference | 66674-16-6(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29221990 | | Storage Class | 11 - Combustible Solids |
| | CBZ-L-ALANINOL Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | N-Benzyloxycarbonyl-L-alaninol is used as an important organic intermediate. It is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | GENERAL METHODS: To a solution of benzyloxycarbonyl-L-alanine (10 mmol) in tetrahydrofuran (THF, 10 mL) was added N,N-diisopropylethylamine (DIPEA, 11 mmol, 1.42 mL) and a solution of 50% propylphosphonic anhydride (T3P) in ethyl acetate (EtOAc) (20 mmol, 6.36 mL) at 0°C with stirring for about 10 minutes. Then sodium borohydride (NaBH4) aqueous solution (10 mmol, 388 mg, dissolved in 0.3 mL of water) was slowly added to the reaction mixture at the same temperature, and the progress of the reaction was monitored by thin-layer chromatography (TLC) until the reaction was completed. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure, and the crude product was dissolved in ethyl acetate (EtOAc), and the organic phase was washed sequentially with 5% aqueous citric acid (10 mL x 2), 5% aqueous sodium carbonate (Na2CO3) (10 mL x 2), water and saturated saline. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and the solvent was evaporated under reduced pressure to obtain the target compound. | | References | [1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5059 - 5063
[3] Tetrahedron Letters, 1992, vol. 33, # 30, p. 4257 - 4260
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1975 - 1980
[5] Tetrahedron: Asymmetry, 1992, vol. 3, # 11, p. 1401 - 1410 |
| | CBZ-L-ALANINOL Preparation Products And Raw materials |
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