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| | 2-Bromo-5-chloro-3-nitropyridine Basic information |
| | 2-Bromo-5-chloro-3-nitropyridine Chemical Properties |
| Melting point | 75-78°C | | Boiling point | 250.3±35.0 °C(Predicted) | | density | 1.936±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | soluble in Methanol | | pka | -5.53±0.20(Predicted) | | form | Solid | | color | Off-white | | InChI | InChI=1S/C5H2BrClN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H | | InChIKey | VFMIDVIAQMFGGP-UHFFFAOYSA-N | | SMILES | C1(Br)=NC=C(Cl)C=C1[N+]([O-])=O | | CAS DataBase Reference | 75806-86-9(CAS DataBase Reference) |
| | 2-Bromo-5-chloro-3-nitropyridine Usage And Synthesis |
| Chemical Properties | Hoar or pale yellow solid | | Synthesis | To a solution of 2-Amino-5-chloro-3-nitropyridine (10.0 g, 57.6 mmol) in HBr [(31.0 mL (100%), 286.4 mmol)], sodium nitrite (13.8 g, 199.9 mmol) was added dropwise. To the stirred solution, Br2 (10.0 mL, 197.1 mmol)in water was added and stirred at room temperature for 1 h. The reaction mixture was basified with NaHCO3 solution (PH=7), extracted with ethyl acetate, washed with water, and dried over anhydrous Na2SO4. The solvent was removed under vacuum to yield 2-Bromo-5-chloro-3-nitropyridine (10.0 g, 73.0%) as a yellow solid. | | References | [1] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 100
[2] Patent: WO2014/202528, 2014, A1. Location in patent: Page/Page column 97
[3] Synthetic Communications, 2012, vol. 42, # 19, p. 2791 - 2796
[4] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 8, p. 2061 - 2071
[5] Patent: US5801183, 1998, A |
| | 2-Bromo-5-chloro-3-nitropyridine Preparation Products And Raw materials |
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