Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Suppliers list

Company Name:	LAURENT
Tel:	+8618100176782
Email:	sun@laurentpeg.com
Products Intro:	Product Name:BocNH-PEG1-CH2CH2NH2 CAS:127828-22-2 Purity:98% Package:1kg;\|100kg;\|1000kg;

Company Name:	9i LLC
Tel:	+18039569191
Email:	MWan@NiNeiLab.com
Products Intro:	Product Name:tert-butyl N-[2-(2-aminoethoxy)ethyl]carbamate CAS:127828-22-2 Purity:min.98% Package:94USD/1 g Remarks:NA816

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	CAS:127828-22-2 Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Company Name:	career henan chemical co
Tel:	+86-0371-86658258 +8613203830695
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Products Intro:	Product Name:Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) CAS:127828-22-2 Purity:98% Package:1KG;1USD

Company Name:	Accela ChemBio Inc.
Tel:	+1-858-6993322
Email:	info@accelachem.com
Products Intro:	Product Name:N-Boc-2-(2-aminoethoxy)ethylamine CAS:127828-22-2 Purity:>=98% Package:0.25g;1g;5g;10g;25g;100g;500g

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) manufacturers

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Basic information

Product Name:	Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
Synonyms:	Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI);CarbaMic acid, [2-(2-aMinoethoxy)ethyl]-, 1,1-diMethylethyl ester;3-Oxapentane-1,5-diamine, N-BOC protected, 2-(2-Aminoethoxy)ethylamine, N-BOC protected;tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate;N-Boc-2-(2-Aminoethoxy)ethanamine;N-Boc-2-aminoethyl 2-aminoethyl ether;BocNH-PEG₁-CH₂CH₂NH₂;N-Boc-2-(2-amino-ethoxy)-ethylamine
CAS:	127828-22-2
MF:	C9H20N2O3
MW:	204.27
EINECS:	821-336-1
Product Categories:	N-BOC;peg
Mol File:	127828-22-2.mol

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties

Boiling point	321.1±22.0 °C(Predicted)
density	1.023±0.06 g/cm3(Predicted)
refractive index	1.4560 to 1.4600
storage temp.	2-8°C(protect from light)
pka	12.24±0.46(Predicted)
form	clear liquid
color	Colorless to Light orange to Yellow
InChI	InChI=1S/C9H20N2O3/c1-9(2,3)14-8(12)11-5-7-13-6-4-10/h4-7,10H2,1-3H3,(H,11,12)
InChIKey	VULKFBHOEKTQSF-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NCCOCCN

Safety Information

HS Code

2934999090

MSDS Information

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis

Description	t-Boc-N-Amido-PEG1-amine is a small molecule PEG reagent containing an amino group and Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties	Colorless viscous liquid
Uses	Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Synthesis	176220-30-7 127828-22-2 Step 4: Synthesis of tert-butyl [2-(2-aminoethoxy)ethyl]carbamate (58) Under argon protection, tert-butyl (2-(2-azidoethoxy)ethyl)carbamate (57, 5.0 g, 0.0217 mol) was dissolved in methanol (100 mL) and palladium/carbon catalyst (2.5 g, 10 mL) was added. The reaction mixture was stirred overnight at room temperature under hydrogen (50 psi) atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford tert-butyl [2-(2-aminoethoxy)ethyl]carbamate (58, 3.0 g). The resulting product can be used directly in the subsequent reaction without further purification. 1H NMR (400 MHz, MeOD) δ 3.48-3.45 (m, 4H), 3.23-3.20 (t, 2H), 2.77-2.75 (m, 2H), 1.43 (s, 9H).
IC 50	PEGs; Alkyl/ether
References	[1] Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841. DOI:10.1021/acs.orglett.9b01326

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Tag:Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)(127828-22-2) Related Product Information

O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL t-Boc-Amido-PEG28-Amine MPEG4-CH2CH2COOH 20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine N3-PEG4-tBu alpha-aMine-oMega-propionic acid octaethylene glycol alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol) HO-PEG12-tBu 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol alpha, oMega-Dipropionic acid dodecaethylene glycol N3-PEG6-tBu 2,5,8,11-TETRAOXATRIDECANE-13-THIOL BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID Hexaethylene glycol Maleimide-PEG4-NHS Ester 1-Azidohexaethylene Glycol FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL)