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| | 4-Chloro-2-fluorobenzyl alcohol Basic information |
| | 4-Chloro-2-fluorobenzyl alcohol Chemical Properties |
| Boiling point | 227.6±25.0 °C(Predicted) | | density | 1.344±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.68±0.10(Predicted) | | Appearance | White to off-white Solid-Liquid Mixture | | CAS DataBase Reference | 56456-49-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | HazardClass | IRRITANT | | HS Code | 2906290090 |
| | 4-Chloro-2-fluorobenzyl alcohol Usage And Synthesis |
| Synthesis | A solution of 4-chloro-2-fluorobenzoic acid (300mg) in THF (15m1) was added at 0CLiAIH4 (130mg). The suspension was stirred at 0℃ for 16h. The reaction mixture was diluted with EA and aq. A solution of potassium sodium tartrate was stirred for lh at rt. The layers were separated, and the org. phasel was further washed with water. The combined org. layers were dried over MgSO4, filtrated off and evaporated in vacuo. The crude was purified by CC (Buechi Sepacore, 5g cartridge, solvent A: DCM, solvent B: 3N ammonia in MeOH, gradient in %B: 0 to 5, flow rate: 6.0 mI/mm) to afford 224mg of colourless oil 4-Chloro-2-fluorobenzyl alcohol. LCMS: (A) tR = 0.68 mm; [M+H]: not visible.
| | References | [1] Patent: US2012/329788, 2012, A1. Location in patent: Page/Page column 22
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3463 - 3468
[3] Patent: US6100257, 2000, A
[4] Patent: EP1577290, 2005, A1. Location in patent: Page/Page column 107 |
| | 4-Chloro-2-fluorobenzyl alcohol Preparation Products And Raw materials |
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